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Regulation of chromatin by histone modifications
Chromatin is not an inert structure, but rather an instructive DNA scaffold that can respond to external cues to regulate the many uses of DNA. A principle component of chromatin that plays a keyExpand
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Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
Heterochromatin protein 1 (HP1) is localized at heterochromatin sites where it mediates gene silencing. The chromo domain of HP1 is necessary for both targeting and transcriptional repression. In theExpand
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Active genes are tri-methylated at K4 of histone H3
Lysine methylation of histones in vivo occurs in three states: mono-, di- and tri-methyl. Histone H3 has been found to be di-methylated at lysine 4 (K4) in active euchromatic regions but not inExpand
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Retinoblastoma protein recruits histone deacetylase to repress transcription
The retinoblastoma protein (Rb) silences specific genes that are active in the S phase of the cell cycle and which are regulated by E2F transcription factors. Rb binds to the activation domain of E2FExpand
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The CBP co-activator is a histone acetyltransferase
THE CBP protein acts as a transcriptional adaptor for many different transcription factors by directly contacting DNA-bound activators1–7. One mechanism by which CBP is thought to stimulateExpand
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Rb targets histone H3 methylation and HP1 to promoters
In eukaryotic cells the histone methylase SUV39H1 and the methyl-lysine binding protein HP1 functionally interact to repress transcription at heterochromatic sites. Lysine 9 of histone H3 isExpand
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Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells
Blimp1, a transcriptional repressor, has a crucial role in the specification of primordial germ cells (PGCs) in mice at embryonic day 7.5 (E7.5). This SET–PR domain protein can form complexes withExpand
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JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin
Activation of Janus kinase 2 (JAK2) by chromosomal translocations or point mutations is a frequent event in haematological malignancies. JAK2 is a non-receptor tyrosine kinase that regulates severalExpand
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The TAFII250 Subunit of TFIID Has Histone Acetyltransferase Activity
The transcription initiation factor TFIID is a multimeric protein complex composed of TATA box-binding protein (TBP) and many TBP-associated factors (TAF(II)s). TAF(II)s are important cofactors thatExpand
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Histone Deimination Antagonizes Arginine Methylation
Methylation of arginine residues within histone H3 has been linked to active transcription. This modification appears on the estrogen-regulated pS2 promoter when the CARM1 methyltransferase isExpand
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