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Regulation of chromatin by histone modifications
The known histone modifications are described, where they are found genomically and discussed and some of their functional consequences are discussed, concentrating mostly on transcription where the majority of characterisation has taken place. Expand
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
A stepwise model for the formation of a transcriptionally silent heterochromatin is provided: SUV39H1 places a ‘methyl marker’ on histone H3, which is then recognized by HP1 through its chromo domain, which may also explain the stable inheritance of theheterochromatic state. Expand
Active genes are tri-methylated at K4 of histone H3
It is shown that the Saccharomyces cerevisiae Set1 protein can catalyse di- and tri-methylation of K4 and stimulate the activity of many genes, establishing the concept of methyl status as a determinant for gene activity and extending considerably the complexity of histone modifications. Expand
Retinoblastoma protein recruits histone deacetylase to repress transcription
It is shown that Rb associates with a histone deacetylase, HDAC1, through the Rb ‘pocket’ domain, and that active transcriptional repression by Rb may involve the modification of chromatin structure. Expand
The CBP co-activator is a histone acetyltransferase
It is shown that CBP has intrinsic HAT activity, and Targeting CBP-associated H AT activity to specific promoters may be a mechanism by which E1A acts as a transcriptional activator. Expand
Rb targets histone H3 methylation and HP1 to promoters
It is shown that SUV39H1 and HP1 are both involved in the repressive functions of the retinoblastoma (Rb) protein, and Chromatin immunoprecipitations show that Rb is necessary to direct methylation of histone H3, and is necessary for binding of HP1 to the cyclin E promoter. Expand
Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells
It is demonstrated that Blimp1 is involved in a novel transcriptional regulatory complex in the mouse germ-cell lineage, which mediates symmetrical dimethylation of arginine 3 on histone H2A and/or H4 tails (H2A/H4R3me2s). Expand
JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin
Inhibition of JAK2 activity in human leukaemic cells decreases both the expression of the haematopoietic oncogene lmo2 and the phosphorylation of H3Y41 at its promoter, while simultaneously increasing the binding of HP1α at the same site. Expand
The TAFII250 Subunit of TFIID Has Histone Acetyltransferase Activity
Evidence is presented that human TAF(II)250 and its homologs in Drosophila and yeast have histone acetyltransferase (HAT) activity in vitro, which suggests that targeted hist one acetylation at specific promoters by TAF (II) 250 may be involved in mechanisms by which TFIID gains access to transcriptionally repressed chromatin. Expand
Histone Deimination Antagonizes Arginine Methylation
Methylation of arginine residues within histone H3 has been linked to active transcription. This modification appears on the estrogen-regulated pS2 promoter when the CARM1 methyltransferase isExpand