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Uracil Mustard

Known as: Mustard, Uracil, 5-[Di(beta-chloroethyl)amino]uracil, Uracil nitrogen mustard 
Nitrogen mustard derivative of URACIL. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly… 
National Institutes of Health

Related topics

Related topics

22 relations
Alkylating Activity [MoA]Aplastic AnemiaChronic Lymphocytic LeukemiaIn Blood

Broader (1)

Antineoplastic Agents, Alkylating

Narrower (4)

U 8344chloroethylaminouracilfluorodopannordopan glucoside

Papers overview

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Highly Cited
2010
Highly Cited
2010
A phase I trial of PR-104, a nitrogen mustard prodrug activated by both hypoxia and aldo-keto reductase 1C3, in patients with solid tumors
PurposePR-104 is a “pre-prodrug” designed to be activated to a dinitrobenzamide nitrogen mustard cytotoxin by nitroreduction in… 
Highly Cited
1995
Highly Cited
1995
Improved methodology for the detection and quantitation of urinary metabolites of sulphur mustard using gas chromatography-tandem mass spectrometry.
Highly Cited
1991
Highly Cited
1991
Methods for the analysis of thiodiglycol sulphoxide, a metabolite of sulphur mustard, in urine using gas chromatography-mass spectrometry.
Highly Cited
1990
Highly Cited
1990
DNA-directed alkylating agents. 1. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the reactivity of the mustard.
A series of DNA-targeted aniline mustards have been prepared, and their chemical reactivity and in vitro and in vivo cytotoxicity… 
Highly Cited
1980
Highly Cited
1980
Kinetic Data on the Inhibition of High‐affinity Choline Transport into Rat Forebrain Synaptosomes by Choline‐like Compounds and Nitrogen Mustard Analogues
Abstract: A series of choline analogues and nitrogen mustard derivatives were evaluated as inhibitors of high‐affinity transport… 
Highly Cited
1974
Highly Cited
1974
The relationship between chromosomal aberrations, survival and DNA repair in tumour cell lines of differential sensitivity to X-rays and sulphur mustard.
Highly Cited
1969
Highly Cited
1969
Genetics of somatic mammalian cells. IX. Quantitation of mutagenesis by physical and chemical agents
The system previously described for inducing single gene mutations in Chinese hamster cells has been extended to produce… 
Highly Cited
1969
Highly Cited
1969
Inactivation of bacteriophage T7 by mono- and difunctional sulphur mustards in relation to cross-linking and depurination of bacteriophage DNA.
Highly Cited
1969
Highly Cited
1969
Molecular cohesion in plant cell walls. Methylation analysis of pectic polysaccharides from the cotyledons of white mustard.
Methylation analysis was used to characterize the pectic polysaccharides from mustard cotyledons, a tissue with potential for… 
Highly Cited
1968
Highly Cited
1968
In vivo antiviral properties of biologically active compounds. II. Studies with influenza and vaccinia viruses.
The in vivo anti-influenza virus and antivaccinia virus activity of 156 biologically active compounds was determined. One of two… 
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