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Uncoupling Agents

Known as: Agents, Uncoupling 
Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1955-2018
051019552017

Related topics

Related topics

27 relations

Narrower (18)

2,4-Dinitrophenol4,6-dinitro-o-cresolAlamethicinAurovertins
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Broader (1)

Enzyme Inhibitors
In BloodIonophoresOxidative Phosphorylationadministration & dosage
(More)

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Uncoupling Agents
Oxidative Phosphorylation
Enzyme Inhibitors
Ionophores
4,6-dinitro-o-cresol
Pentachlorophenol

Papers overview

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2013
2013
Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler.
Nonalcoholic fatty liver disease (NAFLD) affects one in three Americans and is a major predisposing condition for the metabolic… (More)
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Highly Cited
2007
Highly Cited
2007
Application of blebbistatin as an excitation-contraction uncoupler for electrophysiologic study of rat and rabbit hearts.
BACKGROUND Application of fluorescence imaging of cardiac electrical activity is limited by motion artifacts and/or side effects… (More)
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2004
2004
Fluoride curcumin derivatives: new mitochondrial uncoupling agents.
The mitochondrial effects of two fluoride curcumin derivatives were studied. They induced the collapse of mitochondrial membrane… (More)
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Highly Cited
2004
Highly Cited
2004
Higher respiratory activity decreases mitochondrial reactive oxygen release and increases life span in Saccharomyces cerevisiae.
Increased replicative longevity in Saccharomyces cerevisiae because of calorie restriction has been linked to enhanced… (More)
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2004
2004
The mitochondrial uncoupling agent 2,4-dinitrophenol improves mitochondrial function, attenuates oxidative damage, and increases white matter sparing in the contused spinal cord.
The purpose of this study was to investigate the potential neuroprotective efficacy of the mitochondrial uncoupler 2,4… (More)
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2003
2003
Effects of heart isolation, voltage-sensitive dye, and electromechanical uncoupling agents on ventricular fibrillation.
We tested whether the interventions typically required for optical mapping affect activation patterns during ventricular… (More)
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2003
2003
Conduction slowing by the gap junctional uncoupler carbenoxolone.
BACKGROUND Cellular electrical coupling is essential for normal propagation of the cardiac action potential, whereas reduced… (More)
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1990
1990
31P NMR measurement of mitochondrial uncoupling in isolated rat hearts.
Mitochondrial uncoupling is often invoked as a mechanism underlying cellular dysfunction; however, it has not been possible to… (More)
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1985
1985
Effects of the uncoupling agents FCCP and CCCP on the saltatory movements of cytoplasmic organelles.
Two potent uncoupling agents, carbonylcyanide-4-trifluoromethoxyphenylhydrazone (FCCP) and carbonylcyanide-3… (More)
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1968
1968
Protonic conductance across phospholipid bilayer membranes induced by uncoupling agents for oxidative phosphorylation.
The chemiosmotic coupling hypothesis for oxidative phosphorylation proposed by Mitchell1 postulates that electron transport along… (More)
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