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The effects of alcoholism on skeletal and cardiac muscle.
- A. Urbano-Márquez, R. Estruch, F. Navarro‐López, J. Grau, L. Mont, E. Rubin
- MedicineThe New England journal of medicine
- 16 February 1989
It is concluded that myopathy of skeletal muscle and cardiomyopathy are common among persons with chronic alcoholism and that alcohol is toxic to striated muscle in a dose-dependent manner.
Effects of alcohol on the heart
Patients with alcohol abuse and heart failure should be treated in brief intervention and follow-up programs to prevent further complications from drinking and for long-term management of drinking.
Ionizing radiation activates transcription of the EGR1 gene via CArG elements.
The results demonstrate that x-ray inducibility of the EGR1 gene is conferred by a region containing six serum response or CC(A+T-rich)6GG (CArG) motifs, which indicates that ionizing radiation induces E GR1 transcription through CArG elements.
MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration
It is shown that MICU1 is vital for adaptation to postnatal life and for tissue repair after injury and the importance of regulating MCU under stress conditions when the risk of Ca2+ overload is elevated.
The Effect of Controlled Drinking in Alcoholic Cardiomyopathy
The effect of controlled drinking was evaluated, defined as a daily intake of 20 to 60 g of alcohol per day (one to four standard drinks), in patients with alcoholic cardiomyopathy, as part of a standardized program designed to terminate dependence on alcohol.
Inhibition of protein kinase C by alcohols and anaesthetics
It is reported here that anaesthetics inhibit protein kinase C, a key component in signal transduction, and the potency is a linear function of the octanol–water partition coefficient (the Meyer–Overton rule of anaesthesia).
Alcohol and mitochondria in cardiac apoptosis: mechanisms and visualization.
- G. Hajnóczky, Christopher J. Buzas, P. Pacher, J. Hoek, E. Rubin
- Biology, MedicineAlcoholism, clinical and experimental research
- 1 May 2005
It is proposed that chronic ethanol exposure, in combination with other stress signals, may allow for activation of the PTP by physiological calcium oscillations, providing a trigger for cardiac apoptosis during chronic alcohol abuse.
Sequential production of fatty liver, hepatitis, and cirrhosis in sub-human primates fed ethanol with adequate diets.
- C. Lieber, L. Decarli, E. Rubin
- MedicineProceedings of the National Academy of Sciences…
- 1 February 1975
The demonstration that these lesions can develop despite an adequate diet indicates that in addition to correction of the nutritional status, control of alcohol intake is mandatory for the management of patients with alcoholic liver injury.
Ethanol-induced mobilization of calcium by activation of phosphoinositide-specific phospholipase C in intact hepatocytes.