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Alcohol, Oxidative Stress, and Free Radical Damage
ROS production and oxidative stress in liver cells play a central role in the development of alcoholic liver disease and alcohol reduces the levels of agents that can eliminate ROS (i.e., antioxidants).
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms.
CYP2E1 and oxidative liver injury by alcohol.
Mechanisms of hepatotoxicity.
- H. Jaeschke, G. Gores, A. Cederbaum, J. Hinson, D. Pessayre, J. Lemasters
- Biology, MedicineToxicological Sciences
- 1 February 2002
This review addresses recent advances in specific mechanisms of hepatotoxicity, including inducible nitric oxide synthase knockout mice, where nitration is prevented, but unscavenged superoxide production then causes toxic lipid peroxidation to occur instead.
- A. Cederbaum
- MedicineClinical Liver Disease
Role of oxidative stress in alcohol-induced liver injury
This review summarizes some of the leading pathways and discusses the evidence for their contribution to alcohol-induced liver injury, special emphasis is placed on CYP2E1, which is induced by alcohol and is reactive in metabolizing and activating many hepatotoxins, including ethanol, to reactive products, and in generating ROS.
Oxidative stress, toxicology, and pharmacology of CYP2E1.
It is believed that the linkage between CYP2E1-dependent oxidative stress, mitochondrial injury, and GSH homeostasis contribute to the toxic actions of ethanol on the liver.
Alcohol and oxidative liver injury
A review summarizes some of the leading pathways and discusses the evidence for their contribution to alcohol‐induced liver injury in this research area for the 25th Anniversary Issue of the Journal.
Nrf2 is increased by CYP2E1 in rodent liver and HepG2 cells and protects against oxidative stress caused by CYP2E1
The results suggest that Nrf2 is activated and that levels of protein and mRNA are increased when CYP2E1 is elevated, and plays a key role in the adaptive response against increased oxidative stress caused by CYP 2E1.