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Alcohol, Oxidative Stress, and Free Radical Damage
Reactive oxygen species (ROS) are small, highly reactive, oxygen-containing molecules that are naturally generated in small amounts during the body’s metabolic reactions and can react with and damage… Expand
CYP2E1 and oxidative liver injury by alcohol.
Ethanol-induced oxidative stress seems to play a major role in mechanisms by which ethanol causes liver injury. Many pathways have been suggested to contribute to the ability of ethanol to induce a… Expand
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the… Expand
Mechanisms of hepatotoxicity.
- H. Jaeschke, G. Gores, A. Cederbaum, J. Hinson, D. Pessayre, J. Lemasters
- Medicine, Biology
- Toxicological sciences : an official journal of…
- 1 February 2002
This review addresses recent advances in specific mechanisms of hepatotoxicity. Because of its unique metabolism and relationship to the gastrointestinal tract, the liver is an important target of… Expand
Role of oxidative stress in alcohol-induced liver injury
Reactive oxygen species (ROS) are highly reactive molecules that are naturally generated in small amounts during the body’s metabolic reactions and can react with and damage complex cellular… Expand
Alcohol and oxidative liver injury
Acute and chronic ethanol treatment has been shown to increase the production of reactive oxygen species, lower cellular antioxidant levels, and enhance oxidative stress in many tissues, especially… Expand
- A. Cederbaum
- Clinics in liver disease
This article describes the pathways and factors that modulate blood alcohol levels and metabolism and describes how the body disposes of alcohol. The various factors that play a role in the… Expand
Oxidative stress, toxicology, and pharmacology of CYP2E1.
- A. A. Caro, A. Cederbaum
- Biology, Medicine
- Annual review of pharmacology and toxicology
- 16 January 2004
This review describes some of the biochemical and toxicological properties of CYP2E1, especially as it relates to alcohol metabolism and toxicity and the establishment of human hepatoma HepG2 cell… Expand
Production of formaldehyde during metabolism of dimethyl sulfoxide by hydroxyl radical generating systems.
Cytochrome P450 2E1 contributes to ethanol‐induced fatty liver in mice
Cytochrome P450 2E1 (CYP2E1) is suggested to play a role in alcoholic liver disease, which includes alcoholic fatty liver, alcoholic hepatitis, and alcoholic cirrhosis. In this study, we investigated… Expand