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Alcohol, Oxidative Stress, and Free Radical Damage
ROS production and oxidative stress in liver cells play a central role in the development of alcoholic liver disease and alcohol reduces the levels of agents that can eliminate ROS (i.e., antioxidants). Expand
Mechanisms of hepatotoxicity.
This review addresses recent advances in specific mechanisms of hepatotoxicity, including inducible nitric oxide synthase knockout mice, where nitration is prevented, but unscavenged superoxide production then causes toxic lipid peroxidation to occur instead. Expand
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms. Expand
CYP2E1 and oxidative liver injury by alcohol.
This review article summarizes some of the biochemical and toxicological properties of CYP2E1 and briefly describes the use of cell lines developed to constitutively express CYP1-dependent and cytochrome P450 2E1 knockout mice in assessing the actions of CYE1. Expand
Role of oxidative stress in alcohol-induced liver injury
This review summarizes some of the leading pathways and discusses the evidence for their contribution to alcohol-induced liver injury, special emphasis is placed on CYP2E1, which is induced by alcohol and is reactive in metabolizing and activating many hepatotoxins, including ethanol, to reactive products, and in generating ROS. Expand
Alcohol metabolism.
The pathways and factors that modulate blood alcohol levels and metabolism and how the body disposes of alcohol are described and the kinetics of alcohol elimination in-vivo are discussed. Expand
Oxidative stress, toxicology, and pharmacology of CYP2E1.
  • A. Caro, A. Cederbaum
  • Biology, Medicine
  • Annual review of pharmacology and toxicology
  • 16 January 2004
It is believed that the linkage between CYP2E1-dependent oxidative stress, mitochondrial injury, and GSH homeostasis contribute to the toxic actions of ethanol on the liver. Expand
Alcohol and oxidative liver injury
A review summarizes some of the leading pathways and discusses the evidence for their contribution to alcohol‐induced liver injury in this research area for the 25th Anniversary Issue of the Journal. Expand
Oxidative stress and alcoholic liver disease.
This review describes pathways involved in ROS formation, why ROS are toxic to cells, and how the liver protects itself against ROS, and discusses the evidence for their contribution to alcohol-induced liver injury. Expand
Nrf2 is increased by CYP2E1 in rodent liver and HepG2 cells and protects against oxidative stress caused by CYP2E1
The results suggest that Nrf2 is activated and that levels of protein and mRNA are increased when CYP2E1 is elevated, and plays a key role in the adaptive response against increased oxidative stress caused by CYP 2E1. Expand