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Oxidative damage to proteins: spectrophotometric method for carbonyl assay.
Publisher Summary Oxygen radicals are implicated as an important cause of oxidative modification of proteins which may lead to their rapid degradation. Among the various oxidative modifications ofExpand
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alpha-Lipoic acid as a biological antioxidant.
alpha-Lipoic acid, which plays an essential role in mitochondrial dehydrogenase reactions, has recently gained considerable attention as an antioxidant. Lipoate, or its reduced form, dihydrolipoate,Expand
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Antioxidant and redox regulation of gene transcription
  • C. Sen, L. Packer
  • Biology, Medicine
  • FASEB journal : official publication of the…
  • 1 May 1996
Reactive oxygen species (ROS) are implicated in the pathogenesis of a wide variety of human diseases. Recent evidence suggests that at moderately high concentrations, certain forms of ROS such asExpand
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Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol.
There is growing interest in the biologic activities of plant extracts such as that obtained from the bark of the French maritime pine Pinus maritima, Pycnogenol. Pycnogenol (PYC) is a standardizedExpand
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Redox regulation of NF-kappa B activation.
Cytosolic reactions of the nuclear factor kappa B/inhibitor (NF-kappaB/IkappaB) complex leading to its activation, NF-kappaB translocation into the nucleus, DNA binding, and transactivation have beenExpand
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Neuroprotection by the Metabolic Antioxidant α-Lipoic Acid
Reactive oxygen species are thought to be involved in a number of types of acute and chronic pathologic conditions in the brain and neural tissue. The metabolic antioxidant alpha-lipoate (thiocticExpand
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Factors associated with oxidative stress in human populations.
Oxidation of biomolecules may play a role in susceptibility to a number of diseases. However, there are few large-scale survey data describing oxidative damage that occurs in humans and theExpand
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Neuroprotection by the metabolic antioxidant alpha-lipoic acid.
Reactive oxygen species are thought to be involved in a number of types of acute and chronic pathologic conditions in the brain and neural tissue. The metabolic antioxidant alpha-lipoate (thiocticExpand
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Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin.
We measured enzymic and non-enzymic antioxidants in human epidermis and dermis from six healthy volunteers undergoing surgical procedures. Epidermis was separated from dermis by curettage andExpand
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Thiol homeostasis and supplements in physical exercise.
  • C. Sen, L. Packer
  • Chemistry, Medicine
  • The American journal of clinical nutrition
  • 1 August 2000
Thiols are a class of organic sulfur derivatives (mercaptans) characterized by the presence of sulfhydryl residues. In biological systems, thiols have numerous functions, including a central role inExpand
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