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- Publications
- Influence
Oxidative damage to proteins: spectrophotometric method for carbonyl assay.
- A. Reznick, L. Packer
- Chemistry, Medicine
- Methods in enzymology
- 1994
Publisher Summary Oxygen radicals are implicated as an important cause of oxidative modification of proteins which may lead to their rapid degradation. Among the various oxidative modifications of… Expand
alpha-Lipoic acid as a biological antioxidant.
- L. Packer, E. Witt, H. Tritschler
- Chemistry, Medicine
- Free radical biology & medicine
- 1 August 1995
alpha-Lipoic acid, which plays an essential role in mitochondrial dehydrogenase reactions, has recently gained considerable attention as an antioxidant. Lipoate, or its reduced form, dihydrolipoate,… Expand
Antioxidant and redox regulation of gene transcription
Reactive oxygen species (ROS) are implicated in the pathogenesis of a wide variety of human diseases. Recent evidence suggests that at moderately high concentrations, certain forms of ROS such as… Expand
Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol.
- L. Packer, G. Rimbach, F. Virgili
- Chemistry, Medicine
- Free radical biology & medicine
- 1 September 1999
There is growing interest in the biologic activities of plant extracts such as that obtained from the bark of the French maritime pine Pinus maritima, Pycnogenol. Pycnogenol (PYC) is a standardized… Expand
Redox regulation of NF-kappa B activation.
- L. Flohé, R. Brigelius-Flohé, C. Saliou, M. Traber, L. Packer
- Chemistry, Medicine
- Free radical biology & medicine
- 1997
Cytosolic reactions of the nuclear factor kappa B/inhibitor (NF-kappaB/IkappaB) complex leading to its activation, NF-kappaB translocation into the nucleus, DNA binding, and transactivation have been… Expand
Neuroprotection by the Metabolic Antioxidant α-Lipoic Acid
- L. Packer, H. Tritschler, K. Wessel
- Chemistry
- 1997
Reactive oxygen species are thought to be involved in a number of types of acute and chronic pathologic conditions in the brain and neural tissue. The metabolic antioxidant alpha-lipoate (thioctic… Expand
Factors associated with oxidative stress in human populations.
- G. Block, M. Dietrich, +4 authors L. Packer
- Medicine
- American journal of epidemiology
- 1 August 2002
Oxidation of biomolecules may play a role in susceptibility to a number of diseases. However, there are few large-scale survey data describing oxidative damage that occurs in humans and the… Expand
Neuroprotection by the metabolic antioxidant alpha-lipoic acid.
- L. Packer, H. Tritschler, K. Wessel
- Medicine
- Free radical biology & medicine
- 1997
Reactive oxygen species are thought to be involved in a number of types of acute and chronic pathologic conditions in the brain and neural tissue. The metabolic antioxidant alpha-lipoate (thioctic… Expand
Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin.
- Y. Shindo, E. Witt, D. Han, W. Epstein, L. Packer
- Biology, Medicine
- The Journal of investigative dermatology
- 1994
We measured enzymic and non-enzymic antioxidants in human epidermis and dermis from six healthy volunteers undergoing surgical procedures. Epidermis was separated from dermis by curettage and… Expand
Thiol homeostasis and supplements in physical exercise.
Thiols are a class of organic sulfur derivatives (mercaptans) characterized by the presence of sulfhydryl residues. In biological systems, thiols have numerous functions, including a central role in… Expand