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Tyrosine-Protein Kinase ABL1, human
Known as:
c-ABL Protein
, ABL1
, Proto-Oncogene c-Abl
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Tyrosine-protein kinase ABL1 (1130 aa, ~123 kDa) is encoded by the human ABL1 gene. This protein is involved in tyrosine phosphorylation, signal…
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National Institutes of Health
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Related topics
Related topics
28 relations
ABL1 gene
ATM Signaling Pathway
Apoptosis
Axon Guidance
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Broader (1)
Proto-Oncogene Proteins c-abl
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia.
M. Churchman
,
J. Low
,
+46 authors
C. Mullighan
Cancer Cell
2015
Corpus ID: 12260083
Highly Cited
2014
Highly Cited
2014
RESCUE OF HIPPO CO-ACTIVATOR YAP1 TRIGGERS DNA DAMAGE-INDUCED APOPTOSIS IN HEMATOLOGICAL CANCERS
F. Cottini
,
T. Hideshima
,
+18 authors
G. Tonon
Nature Network Boston
2014
Corpus ID: 29686726
Oncogene-induced DNA damage elicits genomic instability in epithelial cancer cells, but apoptosis is blocked through inactivation…
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Highly Cited
2011
Highly Cited
2011
Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progression.
C. Lucas
,
Robert J. Harris
,
A. Giannoudis
,
M. Copland
,
J. Slupsky
,
R. Clark
Blood
2011
Corpus ID: 27799632
Prospective identification of patients whose chronic myeloid leukemia (CML) will progress to blast crisis is currently not…
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Highly Cited
2005
Highly Cited
2005
Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9;14)(q34;q32).
K. De Keersmaecker
,
C. Graux
,
+8 authors
J. Cools
Blood
2005
Corpus ID: 2292298
The BCR-ABL1 fusion kinase is frequently associated with chronic myeloid leukemia and B-cell acute lymphoblastic leukemia but is…
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Highly Cited
2004
Highly Cited
2004
Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia
C. Graux
,
J. Cools
,
+23 authors
A. Hagemeijer
Nature Genetics
2004
Corpus ID: 8313115
In T-cell acute lymphoblastic leukemia (T-ALL), transcription factors are known to be deregulated by chromosomal translocations…
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Highly Cited
1997
Highly Cited
1997
Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin.
S. Engelender
,
A. Sharp
,
+5 authors
C. Ross
Human Molecular Genetics
1997
Corpus ID: 14275897
Huntington's disease (HD) is an inherited neurodegenerative disease caused by expansion of a polyglutamine repeat in the HD…
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Highly Cited
1997
Highly Cited
1997
Characterization of p150, an Adaptor Protein for the Human Phosphatidylinositol (PtdIns) 3-Kinase
C. Panaretou
,
J. Domin
,
S. Cockcroft
,
M. Waterfield
Journal of Biological Chemistry
1997
Corpus ID: 25874908
Genetic and biochemical studies have shown that the phosphatidylinositol (PtdIns) 3-kinase encoded by the yeast VPS34 gene is…
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Highly Cited
1992
Highly Cited
1992
Cell Cycle—Regulated Binding of c-Abl Tyrosine Kinase to DNA
E. Kipreos
,
Jean Y. J. Wang
Science
1992
Corpus ID: 29228735
The proto-oncogene c-abl encodes a protein tyrosine kinase that is localized in the cytoplasm and the nucleus. The large carboxyl…
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Highly Cited
1990
Highly Cited
1990
Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.
T. Lugo
,
A. Pendergast
,
A. Muller
,
O. Witte
Science
1990
Corpus ID: 26670919
Oncogenic activation of the proto-oncogene c-abl in human leukemias occurs as a result of the addition of exons from the gene bcr…
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Highly Cited
1990
Highly Cited
1990
Protein kinase C phosphorylates P-glycoprotein in multidrug resistant human KB carcinoma cells.
Timothy C. Chamber
,
E. Mcavoy
,
J. Jacobs
,
G. Eilon
Journal of Biological Chemistry
1990
Corpus ID: 28465947
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