Tyrosine-Protein Kinase ABL1, human

Known as: c-ABL Protein, ABL1, Proto-Oncogene c-Abl 
Tyrosine-protein kinase ABL1 (1130 aa, ~123 kDa) is encoded by the human ABL1 gene. This protein is involved in tyrosine phosphorylation, signal… (More)
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
BACKGROUND Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile… (More)
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Highly Cited
2014
Highly Cited
2014
Ponatinib is the only currently approved tyrosine kinase inhibitor (TKI) that suppresses all BCR-ABL1 single mutants in… (More)
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Review
2010
Review
2010
ABL-family proteins comprise one of the best conserved branches of the tyrosine kinases. Each ABL protein contains an SH3-SH2-TK… (More)
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Review
2009
Review
2009
Chronic myeloid leukemia (CML) has been regarded as the paradigmatic example of a malignancy defined by a unique molecular event… (More)
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Highly Cited
2008
Highly Cited
2008
The Philadelphia chromosome, a chromosomal abnormality that encodes BCR–ABL1, is the defining lesion of chronic myelogenous… (More)
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Highly Cited
2004
Highly Cited
2004
In T-cell acute lymphoblastic leukemia (T-ALL), transcription factors are known to be deregulated by chromosomal translocations… (More)
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Highly Cited
2000
Highly Cited
2000
Cancer is thought to arise from multiple genetic events that establish irreversible malignancy. A different mechanism might be… (More)
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Highly Cited
1997
Highly Cited
1997
Huntington's disease (HD) is an inherited neurodegenerative disease caused by expansion of a polyglutamine repeat in the HD… (More)
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Highly Cited
1997
Highly Cited
1997
Genetic and biochemical studies have shown that the phosphatidylinositol (PtdIns) 3-kinase encoded by the yeast VPS34 gene is… (More)
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Highly Cited
1990
Highly Cited
1990
Oncogenic activation of the proto-oncogene c-abl in human leukemias occurs as a result of the addition of exons from the gene bcr… (More)
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