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Proto-Oncogene Proteins c-abl

Known as: c abl Proteins, abl Proto Oncogene Proteins, Proto Oncogene Proteins abl 
Non-receptor tyrosine kinases encoded by the C-ABL GENES. They are distributed in both the cytoplasm and the nucleus. c-Abl plays a role in normal… Expand
National Institutes of Health

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Related topics

11 relations
Fusion Proteins, bcr-ablGenes, ablIn BloodProcess of secretion
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Tyrosine-Protein Kinase ABL1, human

Papers overview

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Highly Cited
2007
Highly Cited
2007
Anaplasma phagocytophilum AnkA secreted by type IV secretion system is tyrosine phosphorylated by Abl‐1 to facilitate infection †
Anaplasma phagocytophilum, the agent of human granulocytic anaplasmosis, is an obligate intracellular bacterium of granulocytes… Expand
Review
2001
Review
2001
The BCR gene and philadelphia chromosome-positive leukemogenesis.
Recent investigations have rapidly added crucial new insights into the complex functions of the normal BCR gene and of the BCR… Expand
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Highly Cited
2000
Highly Cited
2000
The Survival Function of the Bcr-Abl Oncogene Is Mediated by Bad-Dependent and -Independent Pathways: Roles for Phosphatidylinositol 3-Kinase and Raf
ABSTRACT The Bcr-Abl tyrosine kinase constitutively activates cytokine signal transduction pathways that stimulate growth and… Expand
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Highly Cited
2000
Highly Cited
2000
Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation.
A search for c-Abl interacting proteins resulted in the recovery of PSTPIP1, originally identified as a binding protein of the… Expand
Highly Cited
1999
Highly Cited
1999
STAT5 activation by BCR-Abl contributes to transformation of K562 leukemia cells.
Signal transducers and activators of transcription (STATs) belong to a family of transcription factors that were originally… Expand
Highly Cited
1998
Highly Cited
1998
Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase.
The ubiquitously expressed nonreceptor tyrosine kinase c-Abl contains three nuclear localization signals, however, it is found in… Expand
Highly Cited
1997
Highly Cited
1997
A cytoplasmic inhibitor of the JNK signal transduction pathway.
The c-Jun amino-terminal kinase (JNK) is a member of the stress-activated group of mitogen-activated protein (MAP) kinases that… Expand
Highly Cited
1995
Highly Cited
1995
Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity.
A novel cellular protein, Abl-interactor-1 (Abi-1), which specifically interacts with the carboxy-terminal region of Abl… Expand
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Highly Cited
1991
Highly Cited
1991
BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner
BCR-ABL is a chimeric oncogene implicated in the pathogenesis of Philadelphia chromosome-positive human leukemias. BCR first exon… Expand
Highly Cited
1985
Highly Cited
1985
Cell lines and clinical isolates derived from Ph1-positive chronic myelogenous leukemia patients express c-abl proteins with a common structural alteration.
The Philadelphia chromosome (Ph1), observed in greater than 90% of chronic myelogenous leukemia (CML) patients, results from a… Expand
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