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Proto-Oncogene Proteins c-abl

Known as: c abl Proteins, abl Proto Oncogene Proteins, Proto Oncogene Proteins abl 
Non-receptor tyrosine kinases encoded by the C-ABL GENES. They are distributed in both the cytoplasm and the nucleus. c-Abl plays a role in normal… 
National Institutes of Health

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Related topics

11 relations
Fusion Proteins, bcr-ablGenes, ablIn BloodProcess of secretion

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Tyrosine-Protein Kinase ABL1, human

Papers overview

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2015
2015
JAK2 V617F及bcr-abl双阳性慢性粒细胞白血病一例并文献复习
目的 研究慢性粒细胞白血病（CML）中JAK2 V617F基因突变与融合基因bcr-abl 210的关系、患者临床特征及疗效.方法 对1例CML… 
2013
2013
Oncogenes Abl Cellular Transformation by eIF 4 B Phosphorylation by Pim Kinases Plays a Critical Role in
Alterations in translation occur in cancer cells, but the precise pathogenic processes and mechanistic underpinnings are not well… 
2011
2011
The Liddy Shriver Sarcoma Initiative
Desmoplastic small round cell tumor (DSRCT) is an aggressive malignant neoplasm that occurs in adolescents and young adults. This… 
2009
2009
Trio receives Lasker Foundation Clinical Award for breakthroughs in leukemia treatment
When Brian J. Druker was a boy, he wanted to be a baseball player; Nicholas B. Lydon had his sights set on flying jets; Charles L… 
2008
2008
Targeting Genetically and Pharmacologically Rac GTPases in p 190-BCR-ABL + Acute Lymphoblastic Leukemia
Significance and Background: The p190-BCR-ABL oncogene is associated with B progenitor (pro-B) acute lymphoblastic leukemia (ALL… 
2005
2005
Synergistic Interactions between Imatinib and the Novel Phosphoinositide-Dependent Kinase-1 Inhibitor OSU-03012 in Overcoming Imatinib Resistance Running title : Overcome imatinib resistance by a PDK…
Resistance to the Abl kinase inhibitor imatinib has become a critical issue for patients in advanced phases of chronic… 
2005
2005
Tumorigenic activity of the BCR-ABL oncogenes is mediated byBCL 2 ( apoptosis / interleukin 3 / leukemia / Philadelphia chromosome / tumor development )
BCR-ABL is a chimeric oncogene generated by translocation of sequences from the c-abl protein-tyrosine kinase gene on chromosome… 
2000
2000
A role for C-ABL tyrosine kinase in p53 upregulation and apoptosis in B-CLL cells exposed to chlorambucil
1999
1999
Links the Bcr-Abl Oncogene and Ras to the Stress-Activated Protein Kinase Pathway
The Bcr-Abl oncogene, found in Philadelphia chromosomepositive myelogenous leukemia (CML), activates Ras and triggers the stress… 
1998
1998
Activation of protein kinase C d by the c-Abl tyrosine kinase in response to ionizing radiation
The c-Abl protein tyrosine kinase is activated by ionizing radiation (IR) and certain other DNA-damaging agents. The present… 
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