Share This Author
Protein kinase C phosphorylates P-glycoprotein in multidrug resistant human KB carcinoma cells.
Direct resorption of bone by human breast cancer cells in vitro
C cultured human breast cancer cells have the capacity to resorb directly in vitro, independently of osteoclast stimulation, and this shows that bone metastases occur frequency in patients with advanced malignancy.
The role of strain/vendor differences on the outcome of focal ischemia induced by intraluminal middle cerebral artery occlusion in the rat
Comparison of the effects of stimulators and inhibitors of resorption on the release of lysosomal enzymes and radioactive calcium from fetal bone in organ culture.
Several agents at a higher concentration, including dibutyryl cAMP, isobutylmethylxanthine, and the calcium ionophore, A23187, all increased lysosomal enzyme release at the concentration which increased 45Ca release, which caused a significant increase in total β-glucuronidase activity in bone plus medium.
Studies on congenital osteopetrosis in microphthalmic mice using organ cultures: impairment of bone resorption in response to physiologic stimulators
- L. Raisz, H. Simmons, S. Gworek, G. Eilon
- Medicine, BiologyThe Journal of experimental medicine
- 1 April 1977
The results indicate that congenital osteopetrosis in mi mice is due to a generalized defect in the function and hormonal response of osteoclasts and suggests that this cell line is separate from the osteoblast cell line which shows no impairment of hormonal response.
Correlation of protein kinase C translocation, P-glycoprotein phosphorylation and reduced drug accumulation in multidrug resistant human KB cells.
Osteoclast activating factor : its role in myeloma and other types of hypercalcaemia of malignancy
The ultrastructure of osteoclasts in microphthalmic mice.
Heart protein kinase C activity increases during progression of disease in the cardiomyopathic hamster.
Identification of a messenger ribonucleic acid fraction in human prostatic cancer cells coding for a novel osteoblast-stimulating factor.
It is shown that conditioned medium from PC-3 cells stimulate mitogenesis and alkaline phosphatase in cells with the osteoblast phenotype (cultured rat osteosarcoma cells) and collagen synthesis in fetal rat calvaria.