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Tyrosine Hydroxylase Inhibitor

Any substance that inhibits tyrosine 3-monooxygenase (tyrosine hydroxylase), an enzyme that catalyzes the conversion of tyrosine to… Expand
National Institutes of Health

Papers overview

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2005
2005
Tyrosine and tyramine increase endogenous ganglionic morphine and dopamine levels in vitro and in vivo: cyp2d6 and tyrosine hydroxylase modulation demonstrates a dopamine coupling.
BACKGROUND The ability of animals to make morphine has been in question for the last 30 years. Studies have demonstrated that… Expand
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Highly Cited
2001
Highly Cited
2001
Regulation of the vesicular monoamine transporter-2: a novel mechanism for cocaine and other psychostimulants.
The plasmalemmal dopamine (DA) transporter (DAT) is a principal site of action for cocaine. This report presents the novel… Expand
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1998
1998
Hyperleptinaemia in mice induced by administration of the tyrosine hydroxylase inhibitor alpha-methyl-p-tyrosine.
Alpha-methyl-p-tyrosine (alphaMPT), an inhibitor of tyrosine hydroxylase, was administered to mice to block noradrenaline… Expand
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Highly Cited
1997
Highly Cited
1997
Imaging D2 Receptor Occupancy by Endogenous Dopamine in Humans
The impact of endogenous dopamine on in vivo measurement of D2 receptors in humans was evaluated with single photon emission… Expand
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Highly Cited
1996
Highly Cited
1996
Catecholamines are synthesized by mouse lymphocytes and regulate function of these cells by induction of apoptosis.
The immune and the nervous systems are anatomically closely related and interact with each other by molecules common to both… Expand
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Highly Cited
1996
Highly Cited
1996
Clinical and biochemical effects of catecholamine depletion on antidepressant-induced remission of depression.
BACKGROUND Most hypotheses of the therapeutic mechanism of action of antidepressant drugs have focused on the role of the… Expand
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Highly Cited
1985
Highly Cited
1985
Electrochemical, pharmacological and electrophysiological evidence of rapid dopamine release and removal in the rat caudate nucleus following electrical stimulation of the median forebrain bundle.
Fast cyclic voltammetry was used to monitor the release of electroactive material in the striatum following electrical… Expand
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1985
1985
Nerve terminal damage in cerebral ischemia: protective effect of alpha-methyl-para-tyrosine.
Mongolian gerbils were treated with alpha-methyl-para-tyrosine methyl ester (AMPT, a tyrosine hydroxylase inhibitor), in order to… Expand
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Highly Cited
1972
Highly Cited
1972
Simultaneous measurement of tyrosine and tryptophan hydroxylase activities in brain in Vivo using an inhibitor of the aromatic amino acid decarboxylase
SummaryDOPA and 5-HTP accumulated in vivo in rat brain after decarboxylase inhibition with NSD 1015 (3-hydroxybenzylhydrazine… Expand
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Highly Cited
1972
Highly Cited
1972
Inhibition of ethanol-induced excitation in mice and rats by α-methyl-p-tyrosine
Small doses of ethanol (1 or 2 g/kg 20% w/v) caused increased motor activity in rats and mice as measured by an Animex activity… Expand
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