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Tyrosine Hydroxylase Inhibitor

Any substance that inhibits tyrosine 3-monooxygenase (tyrosine hydroxylase), an enzyme that catalyzes the conversion of tyrosine to… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
In vivo comparison of norepinephrine and dopamine release in rat brain by simultaneous measurements with fast‐scan cyclic voltammetry
J. Neurochem. (2011) 119, 932–944. 
Highly Cited
2004
Highly Cited
2004
Simultaneous measurement of tyrosine and tryptophan hydroxylase activities in brain in Vivo using an inhibitor of the aromatic amino acid decarboxylase
SummaryDOPA and 5-HTP accumulated in vivo in rat brain after decarboxylase inhibition with NSD 1015 (3-hydroxybenzylhydrazine… Expand
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Highly Cited
2001
Highly Cited
2001
Regulation of the vesicular monoamine transporter-2: a novel mechanism for cocaine and other psychostimulants.
The plasmalemmal dopamine (DA) transporter (DAT) is a principal site of action for cocaine. This report presents the novel… Expand
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Highly Cited
1998
Highly Cited
1998
Hyperleptinaemia in mice induced by administration of the tyrosine hydroxylase inhibitor α‐methyl‐p‐tyrosine
α‐methyl‐p‐tyrosine (αMPT), an inhibitor of tyrosine hydroxylase, was administered to mice to block noradrenaline synthesis. Ten… Expand
Highly Cited
1997
Highly Cited
1997
Imaging D2 Receptor Occupancy by Endogenous Dopamine in Humans
The impact of endogenous dopamine on in vivo measurement of D2 receptors in humans was evaluated with single photon emission… Expand
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Highly Cited
1996
Highly Cited
1996
Catecholamines are synthesized by mouse lymphocytes and regulate function of these cells by induction of apoptosis
The immune and the nervous systems are anatomically closely related and interact with each other by molecules common to both… Expand
Highly Cited
1989
Highly Cited
1989
D1 dopamine receptor stimulation enables the postsynaptic, but not autoreceptor, effects of D2 dopamine agonists in nigrostriatal and mesoaccumbens dopamine systems
Possible functional interactions between D1 and D2 dopamine (DA) receptors were examined using extracellular single‐cell… Expand
Highly Cited
1987
Highly Cited
1987
Reversibility of catecholamine-induced dilated cardiomyopathy in a child with a pheochromocytoma.
PATIENTS with a severe, dilated cardiomyopathy with congestive heart failure have a poor prognosis unless a correctable cause can… Expand
Highly Cited
1985
Highly Cited
1985
Electrochemical, pharmacological and electrophysiological evidence of rapid dopamine release and removal in the rat caudate nucleus following electrical stimulation of the median forebrain bundle.
Fast cyclic voltammetry was used to monitor the release of electroactive material in the striatum following electrical… Expand
Highly Cited
1977
Highly Cited
1977
Evidence for depressed catecholamine and enhanced serotonin metabolism in aging male rats: posssible relation to gondotropin secretion.
The steady state concentration of dopamine (DA), norepinephrine (NE), and serotonin (5HT) was determined and turnover estimated… Expand
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