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Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system.
TLDR
The nigrostriatal dopamine system of rats is unilaterally lesioned by intracerebral injection of 6-hydroxy-dopamine which produces an almost complete and selective lesion and the remaining contralateral dopamine system is activated by systemic treatment with amphetamine. Expand
Stereotaxic mapping of the monoamine pathways in the rat brain.
  • U. Ungerstedt
  • Biology, Medicine
  • Acta physiologica Scandinavica. Supplementum
  • 1 December 1971
TLDR
The ascending monoamine pathways in the rat brain are demonstrated by the pile up of fluorescent material occurring in the axons after various types of lesions, indicating a unique role for the locus coeruleus in influencing the activity of the entire brain. Expand
6-Hydroxy-dopamine induced degeneration of central monoamine neurons.
  • U. Ungerstedt
  • Medicine
  • European journal of pharmacology
  • 1 December 1968
TLDR
It is suggested that intracerebral administration of 6-hydroxy-dopamine may be used as a tool for anatomical and functional studies on central monoamine neurons. Expand
Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system.
  • U. Ungerstedt
  • Chemistry, Medicine
  • Acta physiologica Scandinavica. Supplementum
  • 1 December 1971
TLDR
A process for the treatment of sewage wherein the sludge is innoculated with a bacteria, L. plantarum, and a carbohydrate such as lactose is admixed therewith results in the elimination of pathogenic bacteria and renders theSludge suitable for use as a soil extender without any further environmental constraints. Expand
Microdialysis—principles and applications for studies in animals and man
TLDR
The technique has been extensively used in the neurosciences to monitor neurotransmitter release, and is now finding application in monitoring of the chemistry of peripheral tissues in both animal and human studies. Expand
Striatal dopamine release after amphetamine or nerve degeneration revealed by rotational behaviour.
  • U. Ungerstedt
  • Chemistry, Medicine
  • Acta physiologica Scandinavica. Supplementum
  • 1 December 1971
TLDR
Amphetamine induced vigorous rotational behaviour in rats where the nigrostriatal dopamine system was unilaterally degenerated by an intracerebral injection of 6-hydroxydopamine (6-OH-DA) and evidence was obtained that the amphetamine induced release of DA was dependent upon nerve impulses. Expand
Regional distribution and extracellular levels of amino acids in rat central nervous system.
The extracellular levels of aspartate, glutamate, serine, glutamine, glycine, alanine and GABA were studied in vivo with the microdialysis technique in 15 different regions of the rat brain. TheExpand
Intracerebral Microdialysis in Clinical Practice: Baseline Values for Chemical Markers during Wakefulness, Anesthesia, and Neurosurgery
TLDR
The study provides human baseline levels for biochemical markers that can presently be measured at the bedside during neurointensive care and some changes that occurred under varying physiological conditions are described. Expand
Adipsia and aphagia after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system.
  • U. Ungerstedt
  • Medicine
  • Acta physiologica Scandinavica. Supplementum
  • 1 December 1971
TLDR
It was concluded that bilateral complete degeneration of the nigro-striatal DA pathway produces severe, long lasting adipsia and aphagia, hypoactivity, difficulties to initiate activity and loss of exploratory behaviour and curiosity. Expand
A direct comparison of amphetamine-induced behaviours and regional brain dopamine release in the rat using intracerebral dialysis
TLDR
Measurements of DA release add further support to the hypothesis that amphetamine-induced stereotypy and locomotion are mediated via DA released in striatum and n. Expand
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