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Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects.
TLDR
This finding indicates that neuroleptic-induced extrapyramidal syndromes are related to the degree of central D2 occupancy induced in the basal ganglia of drug-treated schizophrenic patients and demonstrates that clozapine is also "atypical" with respect to the central D1 occupancy in patients.
Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers
TLDR
The results suggest that DRD2 genotypes may participate differentially in the regulation of striatal dopamine D2 receptor density in healthy human subjects.
Quantitative analysis of D2 dopamine receptor binding in the living human brain by PET.
TLDR
Studies of [11C]raclopride binding indicate that clinically effective doses of chemically distinct neuroleptic drugs result in 85 to 90 percent occupancy of D2 dopamine receptors in the putamen of schizophrenic patients.
Distribution of D1- and D2-Dopamine Receptors, and Dopamine and Its Metabolites in the Human Brain
TLDR
Both dopamine receptor subtypes, as well as dopamine, HVA and DOPAC, were primarily found in the basal ganglia, and the receptor distribution in the autoradiographic study was consistent with that demonstrated in the living human brain using [11C].
Central D2-dopamine receptor occupancy in schizophrenic patients treated with antipsychotic drugs.
TLDR
Clinical doses of all the currently used classes of antipsychotic drugs cause a substantial blockade of central D2-dopamine receptors in humans, and this effect appears to be selective for the antipsychotics.
PET study of the pre- and post-synaptic dopaminergic markers for the neurodegenerative process in Huntington's disease.
TLDR
The correlation between the duration of illness and decline of D1- and D2-receptors make these receptors valuable as quantitative markers for the Huntington's disease degenerative process.
BDNF gene variants and brain morphology in schizophrenia
TLDR
Investigation of putative associations between brain‐derived neurotrophic factor gene (BDNF) polymorphisms and brain morphology in patients with schizophrenia and healthy control subjects found trends for associations between several polymorphisms/haplotype estimates and MRI volumes were found.
Autoradiographic localization of extrastriatal D2‐dopamine receptors in the human brain using [125I]epidepride
TLDR
Competition studies indicated that most of the [125I]epidepride binding represented predominantly D2‐dopamine receptors, in striatal as well as in extrastriatal regions, of particular interest for research on schizophrenia and antipsychotic drug action.
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