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Tumor Suppressor Genes

Known as: Antioncogene, Emerogenes, Genes, Cancer Suppressor 
Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor… 
National Institutes of Health

Related topics

Related topics

49 relations
ANP32D proteinAbsent in melanoma 1 proteinBCSC-1 ProteinBRCA3 Protein

Narrower (7)

CDK2AP2 protein, humanPERP protein, humanPlagl1 protein, mouseRetinoblastoma Genes

Broader (1)

Genes

Papers overview

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Highly Cited
2005
Highly Cited
2005
Activation of Wild Type p53 Function by Its Mortalin-binding, Cytoplasmically Localizing Carboxyl Terminus Peptides*
The Hsp70 family member mortalin (mot-2/mthsp70/GRP75) binds to a carboxyl terminus region of the tumor suppressor protein p53… 
Review
2004
Review
2004
Tuberous sclerosis complex: from Drosophila to human disease.
Highly Cited
2003
Highly Cited
2003
Small ubiquitin-like modifier conjugation regulates nuclear export of TEL, a putative tumor suppressor
Posttranslational modification by small ubiquitin-like modifier (SUMO) conjugation regulates the subnuclear localization of… 
Highly Cited
2002
Highly Cited
2002
RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1
RASSF1A, one of the two major isoforms of the putative tumor suppressor gene RASSF1, located at 3p21.3, is inactivated in a… 
Review
1999
Review
1999
Tumor suppressor gene mutations in mice.
Over the past several years, a number of human tumor suppressor genes have been cloned and characterized. Germline mutations in… 
Highly Cited
1996
Highly Cited
1996
The SH3 domain of the tight junction protein ZO‐1 binds to a serine protein kinase that phosphorylates a region C‐terminal to this domain
Highly Cited
1996
Highly Cited
1996
Nitric oxide induced poly(ADP‐ribose) polymerase cleavage in RAW 264.7 macrophage apoptosis is blocked by Bcl‐2
Highly Cited
1995
Highly Cited
1995
Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations.
The human VHL tumor suppressor gene has been implicated in the inherited disorder von Hippel-Lindau disease and in sporadic renal… 
Highly Cited
1990
Highly Cited
1990
Negative regulation of human c-fos expression by thes retinoblastoma gene product
INACTIVATION of the retinoblastoma susceptibility gene (RB-1) has been associated with the aetiology of many types of human… 
Highly Cited
1989
Highly Cited
1989
Loss of heterozygosity for loci on chromosome 17p in human malignant astrocytoma.
Loss of constitutional heterozygosity for specific chromosomal loci, when found consistently in a particular tumor type, suggests… 
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