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Tumor Suppressor Genes

Known as: Antioncogene, Emerogenes, Genes, Cancer Suppressor 
Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor… 
National Institutes of Health

Related topics

Related topics

49 relations
ANP32D proteinAbsent in melanoma 1 proteinBCSC-1 ProteinBRCA3 Protein

Narrower (7)

CDK2AP2 protein, humanPERP protein, humanPlagl1 protein, mouseRetinoblastoma Genes

Broader (1)

Genes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
1999
Review
1999
p53 mutation spectrum and load: the generation of hypotheses linking the exposure of endogenous or exogenous carcinogens to human cancer.
Highly Cited
1999
Highly Cited
1999
Mutations in serines 15 and 20 of human p53 impair its apoptotic activity
Phosphorylation of the p53 tumor suppressor protein is likely to play an important role in regulating its activity. To study the… 
Highly Cited
1998
Highly Cited
1998
Retinoic acid induced mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60 cell differentiation and growth arrest.
Retinoic acid (RA) activated the extracellular signal-regulated kinase (ERK) 2 mitogen-activated protein kinase (MAPK) of HL-60… 
Highly Cited
1997
Highly Cited
1997
The human myoepithelial cell is a natural tumor suppressor.
Myoepithelial cells, which surround ducts and acini of glandular organs, form a natural border separating proliferating… 
Review
1997
Review
1997
Cytoskeletal and adhesion proteins as tumor suppressors.
Highly Cited
1995
Highly Cited
1995
Regulation of the Sequence-specific DNA Binding Function of p53 by Protein Kinase C and Protein Phosphatases (*)
The p53 tumor suppressor protein is a transcription factor with sequence-specific DNA binding activity that is thought to be… 
Review
1994
Review
1994
Gene therapy for cancer.
Highly Cited
1991
Highly Cited
1991
Transcriptional repression mediated by the WT1 Wilms tumor gene product.
The wt1 gene, a putative tumor suppressor gene located at the Wilms tumor (WT) locus on chromosome 11p13, encodes a zinc finger… 
Highly Cited
1990
Highly Cited
1990
Negative regulation of human c-fos expression by thes retinoblastoma gene product
INACTIVATION of the retinoblastoma susceptibility gene (RB-1) has been associated with the aetiology of many types of human… 
Highly Cited
1975
Highly Cited
1975
Conditional-lethal mutations that suppress genetic defects in morphogenesis by altering structural proteins.
An analysis of revertants of missense mutants in phage P22 has shown: (i) New temperature-sensitive (TS) and cold-sensitive (CS… 
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