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Tumor Suppressor Genes

Known as: Antioncogene, Emerogenes, Genes, Cancer Suppressor 
Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor… 
National Institutes of Health

Related topics

Related topics

49 relations
ANP32D proteinAbsent in melanoma 1 proteinBCSC-1 ProteinBRCA3 Protein

Narrower (7)

CDK2AP2 protein, humanPERP protein, humanPlagl1 protein, mouseRetinoblastoma Genes

Broader (1)

Genes

Papers overview

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Highly Cited
2009
Highly Cited
2009
TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma
Proliferation and survival of Hodgkin and Reed/Sternberg (HRS) cells, the malignant cells of classical Hodgkin lymphoma (cHL… 
Highly Cited
2007
Highly Cited
2007
Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity
Pathway-specific therapy is the future of cancer management. The oncogenic phosphatidylinositol 3-kinase (PI3K) pathway is… 
Highly Cited
2006
Highly Cited
2006
Delineation of a Fat tumor suppressor pathway
Recent studies in Drosophila melanogaster of the protocadherins Dachsous and Fat suggest that they act as ligand and receptor… 
Highly Cited
2005
Highly Cited
2005
Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway.
TGF-beta can signal by means of Smad transcription factors, which are quintessential tumor suppressors that inhibit cell… 
Review
2004
Review
2004
Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors.
Mammalian epithelial tumors lose polarity as they progress toward malignancy, but whether polarity loss might causally contribute… 
Highly Cited
2001
Highly Cited
2001
Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes.
To investigate the role of an activated K-Ras gene in the initiation and maintenance of lung adenocarcinomas, we developed… 
Highly Cited
1999
Highly Cited
1999
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.
The von Hippel-Lindau (VHL) tumor suppressor gene is mutated in most human kidney cancers. The VHL protein is part of a complex… 
Highly Cited
1997
Highly Cited
1997
TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta.
It has long been postulated that protein tyrosine phosphatases may act as tumor suppressors because of their ability to… 
Highly Cited
1996
Highly Cited
1996
Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.
The recently identified cyclin-dependent kinase inhibitor p15INK4B is localized to a region on chromosome 9p21 frequently deleted… 
Highly Cited
1992
Highly Cited
1992
Accumulation of p53 tumor suppressor gene protein: an independent marker of prognosis in breast cancers.
BACKGROUND Mutations of the tumor suppressor gene p53 have been identified in breast cancer cell lines, and some breast… 
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