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Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo
Hematopoietic stem cells (HSC) are multipotent cells that reside in the bone marrow and replenish all adult hematopoietic lineages throughout the lifetime of the animal. While experimenting withExpand
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Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.
To compare the ability of different cytokines and other molecules to enhance the immunogenicity of tumor cells, we generated 10 retroviruses encoding potential immunomodulators and studied theExpand
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Dystrophin expression in the mdx mouse restored by stem cell transplantation
The development of cell or gene therapies for diseases involving cells that are widely distributed throughout the body has been severely hampered by the inability to achieve the disseminated deliveryExpand
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Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
The c-abl proto-oncogene, which encodes a cytoplasmic protein-tyrosine kinase, is expressed throughout murine gestation and ubiquitously in adult mouse tissues. However, its levels are highest inExpand
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PTH/PTHrP Receptor in Early Development and Indian Hedgehog--Regulated Bone Growth
The PTH/PTHrP receptor binds to two ligands with distinct functions: the calcium-regulating hormone, parathyroid hormone (PTH), and the paracrine factor, PTH-related protein (PTHrP). Each ligand, inExpand
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Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.
The parathyroid hormone-related peptide (PTHrP) gene was disrupted in murine embryonic stem cells by homologous recombination, and the null allele was introduced into the mouse germ line. MiceExpand
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Demonstration that CFTR is a chloride channel by alteration of its anion selectivity.
Expression of the cystic fibrosis transmembrane conductance regulator (CFTR) generates adenosine 3',5'-monophosphate (cAMP)-regulated chloride channels, indicating that CFTR is either a chlorideExpand
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"Stemness": Transcriptional Profiling of Embryonic and Adult Stem Cells
The transcriptional profiles of mouse embryonic, neural, and hematopoietic stem cells were compared to define a genetic program for stem cells. A total of 216 genes are enriched in all three types ofExpand
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Physiological consequences of loss of plasminogen activator gene function in mice
Indirect evidence suggests a crucial role for the fibrinolytic system and its physiological triggers, tissue-type (t-PA) and urokinase-type (u-PA) plasminogen activator, in many proteolyticExpand
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The basic science of gene therapy.
The development over the past decade of methods for delivering genes to mammalian cells has stimulated great interest in the possibility of treating human disease by gene-based therapies. However,Expand
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