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MicroRNA expression profiles classify human cancers
TLDR
A new, bead-based flow cytometric miRNA expression profiling method is used to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers, and finds the miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tumours. Expand
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
TLDR
It is demonstrated that specific lincRNAs are transcriptionally regulated by key transcription factors in these processes such as p53, NFκB, Sox2, Oct4 (also known as Pou5f1) and Nanog, defining a unique collection of functional linc RNAs that are highly conserved and implicated in diverse biological processes. Expand
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse.
TLDR
It is found that physiological levels of Kras(G12D) induce ductal lesions that recapitulate the full spectrum of human pancreatic intraepithelial neoplasias (PanINs), putative precursors to invasive pancreatic cancer. Expand
Identification of Bronchioalveolar Stem Cells in Normal Lung and Lung Cancer
TLDR
Although bronchiolar cells and alveolar cells are proposed to be the precursor cells of adenocarcinoma, this work points to bronchioalveolar stem cells as the putative cells of origin for this subtype of lung cancer. Expand
Tumor spectrum analysis in p53-mutant mice
TLDR
It is reaffirm that p53 function is not required for normal mouse development and conclude that p 53 status can strongly influence tumor latency and tissue distribution. Expand
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras.
TLDR
It is shown that the use of a recombinant adenovirus expressing Cre recombinase (AdenoCre) to induce K-ras G12D expression in the lungs of mice allows control of the timing and multiplicity of tumor initiation. Expand
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
TLDR
Three participants are identified (AT gene(s), p53, and GADD45) in a signal transduction pathway that controls cell cycle arrest following DNA damage; abnormalities in this pathway probably contribute to tumor development. Expand
Effects of an Rb mutation in the mouse
TLDR
A mouse strain has been constructed in which one allele of Rb is disrupted, and heterozygous animals are not predisposed to retinoblastoma, but some display pituitary tumours arising from cells in which the wild-type Rb allele is absent. Expand
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
TLDR
Observations indicate that TBK1 and NF-κB signalling are essential in KRAS mutant tumours, and establish a general approach for the rational identification of co-dependent pathways in cancer. Expand
A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response
TLDR
A model whereby transcription factors activate lincRNAs that serve as key repressors by physically associating with repressive complexes and modulate their localization to sets of previously active genes is proposed. Expand
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