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Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
TLDR
The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities, and a checklist is provided with summaries of key points. Expand
Regulation of immune responses by extracellular vesicles
TLDR
Given the tremendous therapeutic potential of extracellular vesicles, this Review focuses on their role in modulating immune responses, as well as their potential therapeutic applications. Expand
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
TLDR
The results demonstrate the feasibility of selectively ablating senescent cells and the efficacy of senolytics for alleviating symptoms of frailty and extending healthspan. Expand
A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis
TLDR
It is shown that XIAP associates with the active caspase-9–Apaf-1 holoenzyme complex through binding to the amino terminus of the linker peptide on the small subunit of caspite-9, which becomes exposed after proteolytic processing of procaspases-9 at Asp 315. Expand
Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines
TLDR
Genetic defects that result in up-regulation of β-catenin may play a role in melanoma progression. Expand
Stabilization of beta-catenin by genetic defects in melanoma cell lines.
TLDR
Genetic defects that result in up-regulation of beta-catenin may play a role in melanoma progression. Expand
Negative regulation of the Apaf-1 apoptosome by Hsp70
TLDR
It is proposed that resistance to apoptosis exhibited by stressed cells and some tumours, which constitutively express high levels of Hsp70, may be due in part to modulation of Apaf-1 function by HSp70. Expand
Clonal Isolation of Muscle-Derived Cells Capable of Enhancing Muscle Regeneration and Bone Healing
TLDR
The purification of muscle-derived stem cells from the mdx mouse, an animal model for Duchenne muscular dystrophy, yields a putative muscle- derived stem cell, mc13, that is capable of differentiating into both myogenic and osteogenic lineage in vitro and in vivo. Expand
Cellular Senescence: Defining a Path Forward
TLDR
A consensus from the International Cell Senescence Association (ICSA) is presented, defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers. Expand
Interleukin-17 promotes angiogenesis and tumor growth.
TLDR
A novel role for IL-17 is revealed as a CD4 T-cell-derived mediator of angiogenesis that stimulates vascular endothelial cell migration and cord formation and regulates production of a variety of proangiogenic factors. Expand
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