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Retinoblastoma Genes

Known as: Rb Gene, Gene, Rb, Genes, Retinoblastoma 
Tumor suppressor genes located on human chromosome 13 in the region 13q14 and coding for a family of phosphoproteins with molecular weights ranging… 
National Institutes of Health

Related topics

Related topics

5 relations

Narrower (1)

RB1 gene
Retinoblastomaaspects of radiation effectsphysiological aspects

Broader (1)

Tumor Suppressor Genes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
1995
Review
1995
The retinoblastoma protein as a fundamental mediator of growth and differentiation signals.
The retinoblastoma gene (RB) is the prototype of the tumor suppressor genes, which play critical roles in the genesis of cancer… 
1994
1994
The retinoblastoma binding factor 1 (RBF-1) site in RB gene promoter binds preferentially E4TF1, a member of the Ets transcription factors family.
The tumor suppressor retinoblastoma gene product, pRB, is a well known regulator of G1/S cell cycle progression. Moreover… 
1993
1993
Altered expression of the human retinoblastoma gene in monocytic leukaemias
Summary. Inactivation of the retinoblastoma growth suppressor gene (RB) is responsible for the development of retinoblastomas and… 
1993
1993
One-step purification of recombinant human papillomavirus type 16 E7 oncoprotein and its binding to the retinoblastoma gene product.
Six derivatives of the human papillomavirus type 16 E7 gene were constructed, each of which encoded a peptide at the amino… 
Highly Cited
1992
Highly Cited
1992
Expression of the retinoblastoma gene product in bladder carcinoma cells associates with a low frequency of tumor formation.
Upon inactivation of both alleles of the retinoblastoma gene (RB), individuals develop the intraocular eye tumor, retinoblastoma… 
Highly Cited
1992
Highly Cited
1992
Retinoblastoma gene product Rb accumulates during myogenic differentiation and is deinduced by the expression of SV40 large T antigen.
The cell growth suppression activity of the retinoblastoma gene (RB) product Rb is considered to be regulated by phosphorylation… 
Highly Cited
1991
Highly Cited
1991
Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides
Even though the retinoblastoma gene is one of the best-studied tumor suppressor genes, little is known about its functional role… 
Review
1991
Review
1991
Molecular genetics of the retinoblastoma suppressor gene.
The retinoblastoma gene (RB) is the prototype of a class of genes, called tumor suppressor genes, for which loss-of-function… 
1991
1991
Intraocular tumor suppression of retinoblastoma gene-reconstituted retinoblastoma cells.
Human retinoblastoma is caused by mutational inactivation of the retinoblastoma suppressor gene (RB). We have examined… 
Highly Cited
1989
Highly Cited
1989
Genomic organization of the human retinoblastoma gene.
Sequence analysis of the human retinoblastoma gene cDNA revealed the presence of repeated elements in the form of direct repeats… 
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