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Retinoblastoma Genes

Known as: Rb Gene, Gene, Rb, Genes, Retinoblastoma 
Tumor suppressor genes located on human chromosome 13 in the region 13q14 and coding for a family of phosphoproteins with molecular weights ranging… 
National Institutes of Health

Related topics

Related topics

5 relations

Narrower (1)

RB1 gene
Retinoblastomaaspects of radiation effectsphysiological aspects

Broader (1)

Tumor Suppressor Genes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1997
Highly Cited
1997
Extensive DNA methylation spanning the Rb promoter in retinoblastoma tumors.
The retinoblastoma gene (Rb) is one of the best characterized tumor suppressor genes, and its inactivation is associated with a… 
Highly Cited
1997
Highly Cited
1997
Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinoma.
The retinoblastoma gene family consists of the tumor suppressor protein pRB and its two relatives p107 and p130. These proteins… 
Highly Cited
1996
Highly Cited
1996
pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis.
Mice deficient for the RB gene (RB-/-), prior to death at embryonic day 14.5, show increased cell death in all tissues that… 
Highly Cited
1992
Highly Cited
1992
Identification of a growth suppression domain within the retinoblastoma gene product.
To date, all naturally occurring retinoblastoma susceptibility gene (RB) mutations known to be compatible with stable protein… 
Highly Cited
1992
Highly Cited
1992
The retinoblastoma gene in breast cancer: allele loss is not correlated with loss of gene protein expression.
The significance of the retinoblastoma gene (RB) in the development of human breast cancer remains unclear. In the present study… 
Highly Cited
1991
Highly Cited
1991
The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.
Human cervical carcinoma cell lines that were either positive or negative for human papillomavirus (HPV) DNA sequences were… 
Highly Cited
1991
Highly Cited
1991
Cyclin A and the retinoblastoma gene product complex with a common transcription factor
THE retinoblastoma gene (Rb) product is a negative regulator of cellular proliferation1, an effect that could be mediated in part… 
Highly Cited
1990
Highly Cited
1990
Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene.
Introduction of a normal retinoblastoma gene (RB) into retinoblastoma cells was previously shown to suppress several aspects of… 
Highly Cited
1990
Highly Cited
1990
Promoter deletion and loss of retinoblastoma gene expression in human prostate carcinoma.
Mutational inactivation of the retinoblastoma gene (RB) is found in all retinoblastomas and in a subset of other human neoplasms… 
Highly Cited
1989
Highly Cited
1989
Structure of the human retinoblastoma gene.
Complete inactivation of the human retinoblastoma gene (RB) is believed to be an essential step in tumorigenesis of several… 
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