Retinoblastoma

Known as: Glioblastomas, Retinal, RB1, disorders retinoblastoma 
A malignant tumor that originates in the nuclear layer of the retina. As the most common primary tumor of the eye in children, retinoblastoma is… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1945-2018
010020030019452017

Papers overview

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Highly Cited
2012
Highly Cited
2012
Retinoblastoma is an aggressive childhood cancer of the developing retina that is initiated by the biallelic loss of RB1. Tumours… (More)
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Highly Cited
2007
Highly Cited
2007
Changes in histone methylation status regulate chromatin structure and DNA-dependent processes such as transcription. Recent… (More)
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Highly Cited
2006
Highly Cited
2006
Most human tumours have genetic mutations in their Rb and p53 pathways, but retinoblastoma is thought to be an exception. Studies… (More)
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Highly Cited
1998
Highly Cited
1998
The retinoblastoma protein (Rb) silences specific genes that are active in the S phase of the cell cycle and which are regulated… (More)
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Highly Cited
1996
Highly Cited
1996
Rb protein is a critical regulator of entry into the cell cycle, and loss of Rb function by deletions, mutations, or interaction… (More)
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Highly Cited
1991
Highly Cited
1991
Inactivation of the retinoblastoma gene appears to have a fundamental role in the genesis of retinoblastoma, osteosarcoma, and… (More)
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Highly Cited
1990
Highly Cited
1990
In this issue of the journal, Kreisle and associates (/) report that angiogenesis and growth of B16 melanoma decreased with age… (More)
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Highly Cited
1989
Highly Cited
1989
p105-RB is the product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein hypothesized to act as an… (More)
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Highly Cited
1986
Highly Cited
1986
The genomes of various tumour cells contain mutant oncogenes that act dominantly, in that their effects can be observed when they… (More)
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Highly Cited
1971
Highly Cited
1971
Based upon observations on 48 cases of retinoblastoma and published reports, the hypothesis is developed that retinoblastoma is a… (More)
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