Aging Reduces Proliferative Capacities of Liver by Switching Pathways of C/EBPα Growth Arrest

  title={Aging Reduces Proliferative Capacities of Liver by Switching Pathways of C/EBPα Growth Arrest},
  author={Polina A Iakova and Samir S. Awad and Nikolai A. Timchenko},
The liver is capable of completely regenerating itself in response to injury and after partial hepatectomy. In liver of old animals, the proliferative response is dramatically reduced, the mechanism for which is unknown. The liver specific protein, C/EBPalpha, normally arrests proliferation of hepatocytes through inhibiting cyclin dependent kinases (cdks). We present evidence that aging switches the liver-specific pathway of C/EBPalpha growth arrest to repression of E2F transcription. We… CONTINUE READING
Highly Cited
This paper has 96 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 49 extracted citations

MRGing Chromatin Dynamics and Cellular Senescence

Cell Biochemistry and Biophysics • 2008
View 12 Excerpts
Method Support
Highly Influenced

96 Citations

Citations per Year
Semantic Scholar estimates that this publication has 96 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 32 references

Liver regeneration 4: transcriptional control of liver regeneration.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 1996
View 4 Excerpts
Highly Influenced

c-Myc is a critical target for c/EBPalpha in granulopoiesis.

Molecular and cellular biology • 2001
View 3 Excerpts
Highly Influenced

C / EBP  triggers proteasomedependent degradation of cdk 4 during growth arrest

T. Goode, P. Iakova, J. Albrecht, N. A. Timchenko
EMBO J . • 2002

The identification of E 2 F 1specific target genes

J. Pathobi-Wells, C. R. Graveel, +6 authors P. J. Schacter
Proc . D . • 2002

C-myc antisense

M. T. 2001. Reddy, D. D. Weller, P. L. Iversen