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Photodynamic Therapy
Photodynamic therapy involves administration of a tumor-localizing photosensitizing agent, which may require metabolic synthesis (i.e., a prodrug), followed by activation of the agent by light of aExpand
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Identification of singlet oxygen as the cytotoxic agent in photoinactivation of a murine tumor.
Singlet oxygen, a metastable state of normal triplet oxygen, has been identified as the cytotoxic agent that is probably responsible for in vitro inactivation of TA-3 mouse mammary carcinoma cellsExpand
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Chemotherapy plus local treatment in the management of intraocular retinoblastoma.
OBJECTIVE To describe platinum-based chemotherapy combined with local treatment modalities as an alternative to external beam radiotherapy for intraocular retinoblastoma. DESIGN Platinum levelsExpand
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PRECLINICAL EXAMINATION OF FIRST and SECOND GENERATION PHOTOSENSITIZERS USED IN PHOTODYNAMIC THERAPY
  • C. Gomer
  • Chemistry, Medicine
  • Photochemistry and photobiology
  • 1 December 1991
Numerous photosensitizers with absorption peaks spanning the 600-800 nm "therapeutic window" have been and continue to be synthesized. Structural modifications of the dyes can then be made in orderExpand
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Clinical and preclinical photodynamic therapy
Photodynamic therapy (PDT) is a treatment modality that utilizes a photosensitizing drug activated by laser generated light, and is proving effective for oncologic and nononcologic applications. ThisExpand
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Antiangiogenic treatment enhances photodynamic therapy responsiveness in a mouse mammary carcinoma.
Photodynamic therapy (PDT) is a promising cancer treatment that induces localized tumor destruction via the photochemical generation of cytotoxic singlet oxygen. PDT-mediated oxidative stress elicitsExpand
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Loss of p53 function confers high-level multidrug resistance in neuroblastoma cell lines.
Neuroblastomas can acquire a sustained high-level drug resistance during chemotherapy and especially myeloablative chemoradiotherapy. p53 mutations are rare in primary neuroblastomas, but a loss ofExpand
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Cyclooxygenase-2 inhibitor treatment enhances photodynamic therapy-mediated tumor response.
Photodynamic therapy (PDT) continues to be used in the treatment of solid tumors. Clinical results are promising, but the therapy has not been optimized, and tumor recurrences can occur. Recently, itExpand
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Photodynamic therapy-mediated oxidative stress can induce expression of heat shock proteins.
Photodynamic therapy (PDT) is an experimental cancer therapy inducing tumor tissue damage via photosensitizer-mediated oxidative cytotoxicity. A previous report indicates that oxidative stressExpand
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Celecoxib and NS-398 enhance photodynamic therapy by increasing in vitro apoptosis and decreasing in vivo inflammatory and angiogenic factors.
Photodynamic therapy (PDT) elicits both apoptotic and necrotic responses within treated tumors and produces microvascular injury leading to inflammation and hypoxia. PDT also induces expression ofExpand
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