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Transducin-Like Enhancer Protein 1

Known as: TLE1, Enhancer of Split Groucho-Like Protein 1, ESG1 
Transducin-like enhancer protein 1 (770 aa, ~83 kDa) is encoded by the human TLE1 gene. This protein is involved in transcriptional regulation.
National Institutes of Health

Related topics

Related topics

9 relations
Genes, RegulatorNucleoplasmOrganogenesisSignal Transduction

Papers overview

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Highly Cited
2015
Highly Cited
2015
miR-942 promotes cancer stem cell-like traits in esophageal squamous cell carcinoma through activation of Wnt/β-catenin signalling pathway
The Wnt/β-catenin signalling pathway is known to play a vital role in the maintenance of cancer stem cells (CSCs), which are… 
Highly Cited
2010
Highly Cited
2010
TLE1 is a robust diagnostic biomarker for synovial sarcomas and correlates with t(X;18): analysis of 319 cases.
Highly Cited
2007
Highly Cited
2007
Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription.
Sirt1 is an NAD+-dependent deacetylase that plays a role in cellular processes such as transcriptional regulation, stress… 
Highly Cited
2006
Highly Cited
2006
CUL4–DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation
The CUL4–DDB1–ROC1 ubiquitin E3 ligase regulates cell-cycle progression, replication and DNA damage response. However, the… 
Highly Cited
2005
Highly Cited
2005
Gene expression profiling of human sarcomas: insights into sarcoma biology.
Sarcomas are a biologically complex group of tumors of mesenchymal origin. By using gene expression microarray analysis, we aimed… 
Highly Cited
2003
Highly Cited
2003
A homozygous mutation in HESX1 is associated with evolving hypopituitarism due to impaired repressor-corepressor interaction.
The paired-like homeobox gene expressed in embryonic stem cells Hesx1/HESX1 encodes a developmental repressor and is expressed in… 
Highly Cited
2003
Highly Cited
2003
Six3 and Six6 activity is modulated by members of the groucho family
Six3 and Six6 are two genes required for the specification and proliferation of the eye field in vertebrate embryos, suggesting… 
Highly Cited
1999
Highly Cited
1999
PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins.
The PRDI-BF1/Blimp-1 protein is a transcriptional repressor required for normal B-cell differentiation, and it has been… 
Highly Cited
1998
Highly Cited
1998
TLE, the human homolog of groucho, interacts with AML1 and acts as a repressor of AML1-induced transactivation.
The AML1 gene encodes DNA-binding proteins that contain the Runt domain and is found at the breakpoints of some translocations… 
Highly Cited
1996
Highly Cited
1996
Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif.
Groucho is a protein implicated in Notch signaling and involved in segmentation and neural development in Drosophila. Groucho… 
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