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Transducin-Like Enhancer Protein 1

Known as: TLE1, Enhancer of Split Groucho-Like Protein 1, ESG1 
Transducin-like enhancer protein 1 (770 aa, ~83 kDa) is encoded by the human TLE1 gene. This protein is involved in transcriptional regulation.
National Institutes of Health

Related topics

Related topics

9 relations
Genes, RegulatorNucleoplasmOrganogenesisSignal Transduction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone
The transcription factor Hes family basic helix-loop-helix transcription factor 1 (Hes1) is a downstream effector of Notch… 
2018
2018
TLE1 as an indicator of adverse prognosis in pediatric acute lymphoblastic leukemia.
2013
2013
Specificity of TLE1 Expression in Unclassified High-grade Sarcomas for the Diagnosis of Synovial Sarcoma
Expression of the transducin-like enhancer of split 1 (TLE1) by immunohistochemistry (IHC) has been widely used as a biomarker… 
2012
2012
Progress in breast cancer research
Breast cancer is a heterogeneous disease composed of multiple different subtypes with distinct molecular features and clinical… 
2011
2011
Unknown partner for USP6 and unusual SS18 rearrangement detected by fluorescence in situ hybridization in a solid aneurysmal bone cyst.
2010
2010
Characterization of HuH6, Hep3B, HepG2 and HLE liver cancer cell lines by WNT/β - catenin pathway, microRNA expression and protein expression profile.
Somatic mutations in the genes members of WNT/β-catenin pathway, especially in CTNNB1 codifying for β-catenin, have been found to… 
2009
2009
Cofactor-Activated Phosphorylation Is Required for Inhibition of Cortical Neuron Differentiation by Groucho/TLE1
Background Transcriptional co-repressors of the Groucho/transducin-like Enhancer of split (Gro/TLE) family regulate the… 
Highly Cited
2006
Highly Cited
2006
The Polybasic Region That Follows the Plant Homeodomain Zinc Finger 1 of Pf1 Is Necessary and Sufficient for Specific Phosphoinositide Binding*
The plant homeodomain (PHD) zinc finger is one of 14 known zinc-binding domains. PHD domains have been found in more than 400… 
2002
2002
The transcription co-repressor TLE1 interacted with the intracellular region of gp130 through its Q domain
As the common signal transducer for IL-6 family cytokines, gp130 interacts with various signal molecules. Our previous work found… 
Highly Cited
1996
Highly Cited
1996
Affinity for the nuclear compartment and expression during cell differentiation implicate phosphorylated Groucho/TLE1 forms of higher molecular mass in nuclear functions.
The Drosophila protein Groucho is involved in embryonic segmentation and neural development, and is implicated in the Notch… 
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