Cofactor-Activated Phosphorylation Is Required for Inhibition of Cortical Neuron Differentiation by Groucho/TLE1

@article{Buscarlet2009CofactorActivatedPI,
  title={Cofactor-Activated Phosphorylation Is Required for Inhibition of Cortical Neuron Differentiation by Groucho/TLE1},
  author={Manuel Buscarlet and R{\'o}bert Hermann and Rita Lo and Yeman Tang and Kerline Joachim and Stefano Stifani},
  journal={PLoS ONE},
  year={2009},
  volume={4}
}
Background Transcriptional co-repressors of the Groucho/transducin-like Enhancer of split (Gro/TLE) family regulate the expression of a variety of genes and are involved in numerous developmental processes in both invertebrate and vertebrate species. More specifically, Gro/TLE1 participates in mechanisms that inhibit/delay the differentiation of cerebral cortex neural progenitor cells into neurons during mammalian forebrain development. The anti-neurogenic function of Gro/TLE1 depends on the… 

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