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The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): Liver regeneration and neuronal differentiation
TLDR
The properties of a proteinase K-like subtilase, neural apoptosis-regulated convertase 1 (NARC-1), representing the ninth member of the secretory subtilases family, are described, suggesting that NARC- 1 is implicated in the differentiation of cortical neurons.
The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells
TLDR
It is shown in mice that the essential timing mechanism is programmed within individual progenitor cells, and its expression depends solely on cell-intrinsic and environmental factors generated within the clonal lineage.
Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors.
TLDR
It is shown that AML1 and LEF-1 can act, through recruitment of the corepressor TLE1, as transcriptional repressors in TCR regulation and Wnt/Wg signaling.
Two Domains Unique to Osteoblast-Specific Transcription Factor Osf2/Cbfa1 Contribute to Its Transactivation Function and Its Inability To Heterodimerize with Cbfβ
TLDR
The results uncover the unique functional organization of Osf2 by identifying functional domains not shared with other Runt-related proteins that largely control its transactivation and heterodimerization abilities.
Human homologs of a Drosophila Enhancer of Split gene product define a novel family of nuclear proteins
TLDR
Human cDNA clones encoding a family of proteins, designated TLE, that are homologous to the E(spl) m9/10 gene product, as well as a novel Notch–related protein are characterized.
Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif.
TLDR
Results show that Groucho/TLE proteins and Hairy-like/HES proteins are involved in similar interactions in Drosophila and mammals and further suggest that these proteins perform conserved cellular functions.
Role for Runx1 in the Proliferation and Neuronal Differentiation of Selected Progenitor Cells in the Mammalian Nervous System
TLDR
A previously unrecognized role for Runx1 is suggested in coordinating the proliferation and neuronal differentiation of selected populations of neural progenitors.
The Mammalian Basic Helix Loop Helix Protein HES-1 Binds to and Modulates the Transactivating Function of the Runt-related Factor Cbfa1*
TLDR
These findings implicate HES-1 in the transcriptional functions of Cbfa1 and suggest that the concerted activities of Groucho and HES proteins modulate the functions of mammalian Runt-related proteins.
Hes6 Promotes Cortical Neurogenesis and Inhibits Hes1 Transcription Repression Activity by Multiple Mechanisms
TLDR
Hes6 inhibits Hes1-mediated transcriptional repression in cortical neural progenitor cells and promotes the differentiation of cortical neurons, a process that is normally inhibited by Hes1.
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