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The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia
TLDR
MTHFR C677T was linked to a significant 2·4‐fold decreased risk of developing childhood ALL, whereas MTHFR A1298C did not significantly affect the risk of ALL in the authors' population. Expand
Differential expression of 12 histone deacetylase (HDAC) genes in astrocytomas and normal brain tissue: class II and IV are hypoexpressed in glioblastomas
TLDR
A negative correlation between HDAC gene expression and the glioma grade is established suggesting that class II and IV HDACs might play an important role in glioblastomas malignancy. Expand
miR‐29b and miR‐125a regulate podoplanin and suppress invasion in glioblastoma
TLDR
It is demonstrated that these microRNAs directly target the 3′ untranslated region of PDPN and inhibit invasion, apoptosis, and proliferation of glioblastomas and also in CD133‐positive cells. Expand
research paper: Differential expression of HDAC3, HDAC7 and HDAC9 is associated with prognosis and survival in childhood acute lymphoblastic leukaemia
TLDR
The data suggest that higher expression of HDAC7 and HDAC9 is associated with poor prognosis in childhood ALL and could be promising therapeutic targets for the treatment of refractory childhood ALL. Expand
Genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia
TLDR
Results imply that genetic variants of xenobiotic metabolizing genes influence the risk of developing childhood ALL, and carriers of the rare GSTP1 Val allele were at higher risk of ALL. Expand
Polymorphisms of xenobiotic metabolizing enzymes and DNA repair genes and outcome in childhood acute lymphoblastic leukemia.
TLDR
Polymorphisms of NQO1 and TS could be important for patient response to induction therapy and for treatment outcome, according to this study. Expand
Role of the CYP2D6, EPHX1, MPO, and NQO1 genes in the susceptibility to acute lymphoblastic leukemia in Brazilian children
TLDR
It is suggested that, CYP2D6 polymorphisms may play a role in the susceptibility to pediatric ALL, whereas the EPHX1, NQO1, and MPO polymorphisms might have a protective function against leukemogenesis. Expand
Purification and Biochemical Characterization of Native and Pegylated Form of L-Asparaginase from Aspergillus terreus and Evaluation of Its Antiproliferative Activity
L-asparaginase is a chemotherapeutic drug used in the treatment of lymphoblastic leukemia. In the present study, the extracellular L-asparaginase produced by strain (PC-1.7A) of Aspergillus terreusExpand
CYP3A5 and NAT2 gene polymorphisms: role in childhood acute lymphoblastic leukemia risk and treatment outcome
TLDR
It is suggested that CYP3A5*3 polymorphism may play an important role in the risk of childhood ALL and NAT2 variant polymorphisms were analyzed regarding NAT2 metabolizing enzyme polymorphisms. Expand
Gene expression profile analysis of primary glioblastomas and non-neoplastic brain tissue: identification of potential target genes by oligonucleotide microarray and real-time quantitative PCR
TLDR
The present results indicate the presence of 18 overexpressed genes in human primary glioblastomas that may play a significant role in the pathogenesis of these tumors and that deserve further functional investigation as attractive candidates for new therapeutic targets. Expand
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