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Inhibition of cortical astrocyte differentiation by Hes6 requires amino- and carboxy-terminal motifs important for dimerization and phosphorylation.

• Stephanie Belanger-Jasmin, Estelle Llamosas, +4 authors Stefano Stifani
• Journal of neurochemistry
• 2007

Hairy/Enhancer of split (Hes) 6 is a basic helix-loop-helix protein that interacts with the transcriptional co-repressor, Groucho, and antagonizes the neural functions of the Notch pathway. More… (More)

Hes6 inhibits astrocyte differentiation and promotes neurogenesis through different mechanisms.

• Sumit Jhas, Sorana Ciura, +8 authors Stefano Stifani
• The Journal of neuroscience : the official…
• 2006

The mechanisms regulating the generation of cell diversity in the mammalian cerebral cortex are beginning to be elucidated. In that regard, Hairy/Enhancer of split (Hes) 1 and 5 are basic… (More)

Interaction and antagonistic roles of NF-κB and Hes6 in the regulation of cortical neurogenesis.

• Laurent Methot, Robert Hermann, +7 authors Stefano Stifani
• Molecular and cellular biology
• 2013

The involvement of nuclear factor kappa B (NF-κB) in several processes in the postnatal and adult brain, ranging from neuronal survival to synaptogenesis and plasticity, has been documented. In… (More)

Cofactor-Activated Phosphorylation Is Required for Inhibition of Cortical Neuron Differentiation by Groucho/TLE1

• Manuel Buscarlet, Robert Hermann, Rita Lo, Yeman Tang, Kerline Joachim, Stefano Stifani
• PloS one
• 2009

BACKGROUND Transcriptional co-repressors of the Groucho/transducin-like Enhancer of split (Gro/TLE) family regulate the expression of a variety of genes and are involved in numerous developmental… (More)

Zeb1 potentiates genome-wide gene transcription with Lef1 to promote glioblastoma cell invasion.

• Pedro Rosmaninho, Susanne Mükusch, +9 authors Diogo S Castro
• The EMBO journal
• 2018

Glioblastoma is the most common and aggressive brain tumor, with a subpopulation of stem-like cells thought to mediate its recurring behavior and therapeutic resistance. The epithelial-mesenchymal… (More)

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