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Hes6 Inhibits Astrocyte Differentiation and Promotes Neurogenesis through Different Mechanisms
TLDR
Hes6 is an important regulator of the neurogenic phase of cortical development by promoting the neuronal fate while suppressing astrocyte differentiation, and it is suggested further that separate molecular mechanisms underlie the proneuronal and anti-gliogenic activities of Hes6 in cortical progenitor cells.
Inhibition of cortical astrocyte differentiation by Hes6 requires amino‐ and carboxy‐terminal motifs important for dimerization and phosphorylation
TLDR
Observations suggest that Hes6 homodimers regulate astrocyte differentiation through mechanisms that depend on the phosphorylation of Hes6 C‐terminal domain but are independent of its ability to suppress Hes1‐mediated transcriptional repression.
Zeb1 potentiates genome‐wide gene transcription with Lef1 to promote glioblastoma cell invasion
TLDR
It is shown that genome‐wide binding of Zeb1 associates with both activation and repression of gene expression in glioblastoma stem‐like cells, and predicted mediators of tumor cell migration and invasion are predicted, including the guanine nucleotide exchange factor Prex1, whose elevated expression is predictive of shorter gliOBlastoma patient survival.
Cofactor-Activated Phosphorylation Is Required for Inhibition of Cortical Neuron Differentiation by Groucho/TLE1
TLDR
Based on the positive correlation between Gro/TLE1 cofactor-activated phosphorylation and ability to inhibit cortical neuron differentiation, it is proposed that hyperphosphorylation induced by cofactor binding plays a positive role in the regulation of Gro/Nurogenic activity.
Interaction and Antagonistic Roles of NF-κB and Hes6 in the Regulation of Cortical Neurogenesis
TLDR
It is shown here that NF-κB is selectively activated in neocortical neural progenitor cells in the developing mouse telencephalon and exerts an inhibitory effect on the ability of Hes6 to promote cortical neuronal differentiation.
An Arf/Rab cascade controls the growth and invasiveness of glioblastoma
TLDR
A novel GTPase cascade in which Arf5 activates Rab35 increases EGF receptor activation, leading to upregulation of the transcription factor SPOCD1 with enhanced tumor growth and invasion in glioblastoma.
Comparing the potential of microglia preparations generated using different human iPSC-based differentiation methods to model microglia-mediated mechanisms of amyotrophic lateral sclerosis
TLDR
It is shown that microglia derived using two different methods display distinct in vitro maturation characteristics, and that different derivation methods give rise to preparations comprising humanmicroglia with distinct transcriptomic signatures resembling the gene profiles of specific microglian subpopulations in vivo.
An Arf/Rab cascade controls the growth and invasiveness of glioblastoma
TLDR
An unexpected cascade between an Arf and a Rab is revealed and a role for the cascade, and thus endosomal trafficking, in brain tumors is indicated.
Regulation of respiratory motor neuron development in vivo
Groucho/TLE opposes axial to hypaxial motor neuron development
TLDR
It is shown that the Groucho/TLE (TLE) transcriptional corepressor is a multi-step regulator of axial and hypaxial motor neuron diversification in the developing spinal cord.