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RhoE Binds to ROCK I and Inhibits Downstream Signaling
- K. Riento, R. Guasch, R. Garg, Boquan Jin, A. Ridley
- Biology, ChemistryMolecular and Cellular Biology
- 15 June 2003
Overexpression of RhoE inhibited ROCK I-induced stress fiber formation and phosphorylation of the ROCK I target myosin light chain phosphatase, suggesting that R HoE induces stress fiber disassembly by directly binding ROCK I and inhibiting it from phosphorylating downstream targets.
ASPP1 and ASPP2: Common Activators of p53 Family Members
- D. Bergamaschi, Y. Samuels, Boquan Jin, S. Duraisingham, T. Crook, Xin Lu
- BiologyMolecular and Cellular Biology
- 1 February 2004
It is shown that ASPP1 and ASPP2 could suppress tumor growth even in tumors expressing mutant p53, and are the first two identified common activators of all p53 family members.
A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition
The X-ray structure of a receptor binding region of a Notch ligand is reported and a highly conserved face of the DSL domain is revealed, suggesting that cis- and trans-regulation may occur through the formation of structurally distinct complexes that, unexpectedly, involve the same surfaces on both ligand and receptor.
Type 1 regulatory T cells: a new mechanism of peripheral immune tolerance
This review focuses on the discovery, associated biomarkers, regulatory functions, methods of induction, association with disease, and clinical trials of Tr1 cells.
Infection with a Brazilian isolate of Zika virus generates RIG‐I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling
- Jonny Hertzog, Antônio Gregório Dias Júnior, J. Rehwinkel
- Biology, MedicineEuropean journal of immunology
- 6 April 2018
The observations suggest that ZikV infection induces a type I IFN response via RLRs and that ZIKV interferes with this response by blocking signaling downstream of RLRsand IFNAR.
The Soluble Leukocyte-Associated Ig-Like Receptor (LAIR)-2 Antagonizes the Collagen/LAIR-1 Inhibitory Immune Interaction1
- R. Lebbink, M. C. W. van den Berg, L. Meyaard
- Biology, MedicineThe Journal of Immunology
- 1 February 2008
It is shown, for the first time, that the LAIR-2 gene is broadly transcribed in human PBMC, mirroring the expression profile ofLAIR-1, and a novel mechanism of immune regulation by a soluble LAIR receptor regulating the inhibitory potential of the membrane-bound LAir-1 via competition for ligands is revealed.
The LFA-1-associated Molecule PTA-1 (CD226) on T Cells Forms a Dynamic Molecular Complex with Protein 4.1G and Human Discs Large*
It is established that an L FA-1-associated molecule, PTA-1, is localized to membrane rafts and binds the carboxyl-terminal domain of isoforms of the actin-binding protein 4.1G, and proposed that these dynamic associations provide the structural basis for a regulated molecular adhesive complex that serves to cluster and transport LFA-1 and associated molecules.
Expression of TRAIL and TRAIL receptors in normal and malignant tissues
The generation of reliable monoclonal antibodies against TRAIL and its four membrane-bound receptors that can stain fixed specimens will allow a thorough analysis of their expression on normal and malignant tissues and allow assessment of biopsy material, possibly allowing the identification of tumors that may be amenable to TRAIL therapy.
Cellular immune response to Hantaan virus nucleocapsid protein in the acute phase of hemorrhagic fever with renal syndrome: correlation with disease severity.
- Mei-liang Wang, Jiu-ping Wang, Boquan Jin
- Medicine, BiologyThe Journal of infectious diseases
- 15 January 2009
Taken together with published data on the similar associations with neutralizing antibody, these data suggest that IFN-gamma-producing T cells may help reduce the risk of progression to acute renal failure caused by HTNV infection.