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Toll-like receptors

Known as: Toll Like Receptor, Toll-Like Receptors [Chemical/Ingredient], like receptors toll 
A family of pattern recognition receptors characterized by an extracellular leucine-rich domain and a cytoplasmic domain that share homology with the… 
National Institutes of Health

Related topics

Related topics

16 relations
Gene Expression RegulationIn BloodSignal Transductionagonists

Broader (2)

ProteinsReceptors, Cell Surface

Narrower (7)

TLR4 protein, humanTLR7 protein, humanTLR8 protein, humanToll-Like Receptor 1

Papers overview

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Highly Cited
2008
Highly Cited
2008
The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling
The kinases MSK1 and MSK2 are activated 'downstream' of the p38 and Erk1/2 mitogen-activated protein kinases. Here we found that… 
Highly Cited
2006
Highly Cited
2006
IκB kinase-α is critical for interferon-α production induced by Toll-like receptors 7 and 9
The Toll-like receptor (TLR) family has important roles in microbial recognition and dendritic cell activation. TLRs 7 and 9 can… 
Highly Cited
2006
Highly Cited
2006
Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria
Toll-like receptors (TLRs) are key components of the immune system that detect microbial infection and trigger antimicrobial host… 
Review
2006
Review
2006
Exercise and Toll-like receptors.
Toll-like receptors (TLRs) are highly conserved trans-membrane proteins that play an important role in the detection and… 
Review
2005
Review
2005
BACTERIAL INTERACTIONS WITH CELLS OF THE INTESTINAL MUCOSA: TOLL-LIKE RECEPTORS AND NOD2
Toll-like receptors (TLR) and NOD2 are emerging as key mediators of innate host defence in the intestinal mucosa, crucially… 
Highly Cited
2005
Highly Cited
2005
NOD2 and Toll-Like Receptors Are Nonredundant Recognition Systems of Mycobacterium tuberculosis
Infection with Mycobacterium tuberculosis is one of the leading causes of death worldwide. Recognition of M. tuberculosis by… 
Highly Cited
2004
Highly Cited
2004
Activation of airway epithelial cells by toll-like receptor agonists.
Toll-like receptors (TLR) play an important role in pathogen recognition and innate immunity. We investigated the presence and… 
Highly Cited
2004
Highly Cited
2004
Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation.
BACKGROUND AND AIMS Recent evidence suggests that toll-like receptors (TLRs) recognize certain viruses. We reported that… 
Highly Cited
2000
Highly Cited
2000
Cutting Edge: Endotoxin Tolerance in Mouse Peritoneal Macrophages Correlates with Down-Regulation of Surface Toll-Like Receptor 4 Expression1
Monocytes/macrophages exposed to LPS show reduced responses to second stimulation with LPS, which is termed LPS tolerance. In… 
Highly Cited
2000
Highly Cited
2000
Cutting Edge: Cell Surface Expression and Lipopolysaccharide Signaling Via the Toll-Like Receptor 4-MD-2 Complex on Mouse Peritoneal Macrophages1
The human MD-2 molecule is associated with the extracellular domain of human Toll-like receptor 4 (TLR4) and greatly enhances its… 
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