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TLR8 protein, human

Known as: hTLR8, CD288 Antigen, TLR8 
Toll-like receptor 8 (1041 aa, ~120 kDa) is encoded by the human TLR8 gene. This protein is involved in the regulation of antimicrobial responses.
National Institutes of Health

Related topics

Related topics

15 relations
Immune responseIntegral Membrane ProteinsLeucine-Rich RepeatLigand Binding

Broader (2)

Toll-Like Receptor 8Toll-like receptors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
The Bacterial Product Violacein Exerts an Immunostimulatory Effect Via TLR8
Violacein, an indole-derived, purple-colored natural pigment isolated from Chromobacterium violaceum has shown multiple… 
2017
2017
Identification of an optimized 2′-O-methylated trinucleotide RNA motif inhibiting Toll-like receptors 7 and 8
Bacterial RNA serves an important function as activator of the innate immune system. In humans bacterial RNA is sensed by the… 
2015
2015
Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity
Human Toll-like receptor 8 (hTLR8) is expressed in myeloid dendritic cells, monocytes, and monocyte-derived dendritic cells… 
Highly Cited
2013
Highly Cited
2013
Exquisite selectivity for human toll-like receptor 8 in substituted furo[2,3-c]quinolines.
Toll-like receptor (TLR)-8 agonists activate adaptive immune responses by inducing robust production of T helper 1-polarizing… 
Highly Cited
2011
Highly Cited
2011
UNC93B1 Physically Associates with Human TLR8 and Regulates TLR8-Mediated Signaling
Toll-like receptors (TLRs) 3, 7, 8, and 9 are localized to intracellular compartments where they encounter foreign or self… 
2010
2010
C/EBPδ and STAT-1 Are Required for TLR8 Transcriptional Activity*
Toll-like receptor 8 (TLR8), which is expressed primarily in myeloid cells, plays a central role in initiating immune responses… 
Highly Cited
2009
Highly Cited
2009
TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells.
Tumor necrosis factor alpha (TNF-alpha) production is abnormally high in Fanconi anemia (FA) cells and contributes to the… 
2009
2009
Oxidative stress augments toll-like receptor 8 mediated neutrophilic responses in healthy subjects
BackgroundExcessive oxidative stress has been reported to be generated in inflamed tissues and contribute to the pathogenesis of… 
Review
2007
Review
2007
Immunostimulatory activity of Toll-like receptor 8 agonists towards human leucocytes: basic mechanisms and translational opportunities.
TLR8 (Toll-like receptor 8) is activated by ssRNAs (single-stranded RNAs) and synthetic imidazoquinoline compounds that resemble… 
Highly Cited
2006
Highly Cited
2006
Conserved Features in the Extracellular Domain of Human Toll-like Receptor 8 Are Essential for pH-dependent Signaling*
Toll-like receptor (TLR) 8 has an important role in initiating immune responses to viral single-stranded RNA and the antiviral… 
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