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TLR4 protein, human

Known as: toll-like receptor 4, human, Toll Homolog, Toll-Like Receptor 4 
Toll-like receptor 4 (839 aa, ~96 kDa) is encoded by the human TLR4 gene. This protein is involved in regulation of both fatty acid-induced… 
National Institutes of Health

Related topics

Related topics

20 relations
Beta-Catenin Accumulation PathwayDendritic Cell PathwayImmune responseIntegral Membrane Proteins

Broader (2)

Toll-like receptorstoll-like receptor 4

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Emerging Role of Endosomal Toll-Like Receptors in Rheumatoid Arthritis
Toll-like receptors (TLRs) and their downstream signaling pathways have been comprehensively characterized in innate immunity. In… 
Highly Cited
2006
Highly Cited
2006
Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA
Toll-like receptors (TLRs) sense infection by detecting molecular structures of microbial origin. TLR3, TLR7 and TLR9 recognize… 
Highly Cited
2004
Highly Cited
2004
Toll-like Receptor 9–Dependent and –Independent Dendritic Cell Activation by Chromatin–Immunoglobulin G Complexes
Dendritic cell (DC) activation by nucleic acid–containing immunoglobulin (Ig)G complexes has been implicated in systemic lupus… 
Review
2003
Review
2003
NALPs: a novel protein family involved in inflammation
A newly discovered family of cytoplasmic proteins — the NALPs — has been implicated in the activation of caspase-1 by the Toll… 
Highly Cited
2003
Highly Cited
2003
A Toll-like receptor recognizes bacterial DNA
Highly Cited
2003
Highly Cited
2003
The Toll‐like receptor 7 (TLR7)‐specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily
Loxoribine (7‐allyl‐7,8‐dihydro‐8‐oxo‐guanosine) acts as synthetic adjuvant in anti‐tumor responses. Here we first demonstrate… 
Highly Cited
2002
Highly Cited
2002
The Development of Murine Plasmacytoid Dendritic Cell Precursors Is Differentially Regulated by FLT3-ligand and Granulocyte/Macrophage Colony-Stimulating Factor
Plasmacytoid predendritic cells or type 1 interferon (IFN)-producing cells (IPCs) have recently been identified in mice. Although… 
Highly Cited
2002
Highly Cited
2002
Human Toll-like receptor 4 recognizes host-specific LPS modifications
Lipopolysaccharide (LPS) is the principal proinflammatory component of the Gram-negative bacterial envelope and is recognized by… 
Highly Cited
2000
Highly Cited
2000
Cutting Edge: Endotoxin Tolerance in Mouse Peritoneal Macrophages Correlates with Down-Regulation of Surface Toll-Like Receptor 4 Expression1
Monocytes/macrophages exposed to LPS show reduced responses to second stimulation with LPS, which is termed LPS tolerance. In… 
Review
1998
Review
1998
Signal transduction pathways activated by the IL‐1 receptor family: ancient signaling machinery in mammals, insects, and plants
Interleukin‐1 (IL‐1) is a central regulator of the immune and inflammatory responses. Recently, significant advances have been… 
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