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Tocainide

Known as: Propanamide, 2-amino-N-(2,6-dimethylphenyl)-, Alanyl-2,6-xylidide, Tocainide [Chemical/Ingredient] 
An antiarrhythmic agent which exerts a potential- and frequency-dependent block of SODIUM CHANNELS.
National Institutes of Health

Papers overview

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2004
2004
SummaryThe antimyotonic effect of the antiarrhythmic drug tocainide was tested in 14 patients. With 1200 to 1600 mg/d all… Expand
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Review
1998
Review
1998
  • Peter K. Stys
  • Journal of cerebral blood flow and metabolism…
  • 1998
  • Corpus ID: 37501871
White matter of the brain and spinal cord is susceptible to anoxia and ischemia. Irreversible injury to this tissue can have… Expand
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Highly Cited
1989
Highly Cited
1989
The effects of intravenously administered subanesthetic concentrations of lidocaine, tocainide, and mexiletine on spontaneously… Expand
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Highly Cited
1987
Highly Cited
1987
Tocainide is a derivative of lidocaine with anti-arrhythmic action and, unlike lidocaine, can be used for oral treatment… Expand
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Highly Cited
1985
Highly Cited
1985
An electrophysiological analysis of the antinociceptive effects of systemic lidocaine and its longer acting primary amine… Expand
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1983
1983
We investigated the effectiveness of tocainide and hydrochlorothiazide on muscular symptoms in a patient with paramyotonia… Expand
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Highly Cited
1983
Highly Cited
1983
The kinetics of onset of rate-dependent depression of maximum rate of depolarisation (Vmax) of guinea-pig ventricular action… Expand
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Highly Cited
1982
Highly Cited
1982
Antiarrhythmic drugs may aggravate or even induce ventricular arrhythmias. This type of adverse reaction is becoming more… Expand
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1976
1976
Tocainide, a new oral antiarrhythmic agent, was studied in man in a short-term protocol designed to evaluate the efficacy… Expand
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1976
1976
Tocainide, a primary amine analogue of lidocaine, is effective against some experimental and clinical arrhythmias. Its… Expand
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