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Tocainide

Known as: Propanamide, 2-amino-N-(2,6-dimethylphenyl)-, Alanyl-2,6-xylidide, Tocainide [Chemical/Ingredient] 
An antiarrhythmic agent which exerts a potential- and frequency-dependent block of SODIUM CHANNELS.
National Institutes of Health

Related topics

Related topics

17 relations

Broader (2)

Anti-Arrhythmia AgentsVoltage-Gated Sodium Channel Blockers
Drug AllergyHeart BlockIn BloodTocainide Monohydrochloride

Narrower (4)

TonocardW-36095Xylotocanlactoxylidide

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2003
Review
2003
Outpatient prescribing of antiarrhythmic drugs from 1995 to 2000.
1993
1993
Enantiospecific drug analysis via the ortho-phthalaldehyde/homochiral thiol derivatization method.
Review
1991
Review
1991
Fetal and neonatal adverse effects profile of amiodarone treatment during pregnancy.
1990
1990
Two types of sodium channel block by class-I antiarrhythmic drugs studied by using Vmax of action potential in single ventricular myocytes.
Review
1986
Review
1986
Effects of congestive heart failure on the pharmacokinetics and pharmacodynamics of antiarrhythmic agents.
1983
1983
Different effectiveness of tocainide and hydrochlorothiazide in paramyotonia congenita with hyperkalemic episodic paralysis
We investigated the effectiveness of tocainide and hydrochlorothiazide on muscular symptoms in a patient with paramyotonia… 
Highly Cited
1980
Highly Cited
1980
Tocainide kinetics after intravenous and oral administration in healthy subjects and in patients with acute myocardial infarction
Tocainide is structurally related to lidocaine but may be used orally as well as intravenously. A therapeutic plasma… 
Highly Cited
1978
Highly Cited
1978
Liquid chromatography in the monitoring of plasma levels of antiarrhythmic drugs.
Highly Cited
1977
Highly Cited
1977
Suppression of Ventricular Ectopic Depolarizations by Tocainide
In a previous clinical study we demonstrated that tocainide is effective in the suppression of ventricular ectopic… 
Highly Cited
1976
Highly Cited
1976
Kinetics of the oral antiarrhythmie lidocaine congener, tocainide
Tocainide, a primary amine analogue of lidocaine, is effective against some experimental and clinical arrhythmias. Its… 
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