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Tocainide

Known as: Propanamide, 2-amino-N-(2,6-dimethylphenyl)-, Alanyl-2,6-xylidide, Tocainide [Chemical/Ingredient] 
An antiarrhythmic agent which exerts a potential- and frequency-dependent block of SODIUM CHANNELS.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
1998
Review
1998
  • P. Stys
  • Journal of cerebral blood flow and metabolism…
  • 1998
  • Corpus ID: 37501871
White matter of the brain and spinal cord is susceptible to anoxia and ischemia. Irreversible injury to this tissue can have… Expand
Highly Cited
1989
Highly Cited
1989
&NA; The effects of intravenously administered subanesthetic concentrations of lidocaine, tocainide, and mexiletine on… Expand
Highly Cited
1987
Highly Cited
1987
&NA; Tocainide is a derivative of lidocaine with anti‐arrhythmic action and, unlike lidocaine, can be used for oral treatment… Expand
Highly Cited
1983
Highly Cited
1983
  • T. Campbell
  • Cardiovascular research
  • 1983
  • Corpus ID: 23188959
The kinetics of onset of rate-dependent depression of maximum rate of depolarisation (Vmax) of guinea-pig ventricular action… Expand
Highly Cited
1982
Highly Cited
1982
Antiarrhythmic drugs may aggravate or even induce ventricular arrhythmias. This type of adverse reaction is becoming more… Expand
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Highly Cited
1980
Highly Cited
1980
In a double-blind placebo controlled study, tocainide, 750 mg i.v. during a 15-minute period directly followed by 800 mg orally… Expand
Highly Cited
1978
Highly Cited
1978
SUMMARY Long-term tocainide therapy has been evaluated in 17 patients with ventricular arrhythmias. Ventricular tachycardia and… Expand
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Highly Cited
1977
Highly Cited
1977
In a previous clinical study we demonstrated that tocainide is effective in the suppression of ventricular ectopic… Expand
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Highly Cited
1976
Highly Cited
1976
SUMMARY Tocainide, a new oral antiarrhythmic agent, was studied in man in a short-term protocol designed to evaluate the efficacy… Expand
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Highly Cited
1976
Highly Cited
1976
Tocainide, a primary amine analogue of lidocaine, is effective against some experimental and clinical arrhythmias. Its… Expand