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ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult—Summary Article

TLDR
The American College of Cardiology (ACC)/AHA Task Force on Practice Guidelines regularly reviews existing guidelines to determine when an update or full revision is needed.
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Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials

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Effects of caffeine on plasma renin activity, catecholamines and blood pressure.

TLDR
Under the conditions of study caffeine was a potent stimulator of plasma renin activity and adrenomedullary secretion and whether habitual ingestion has similar effects remains to be determined.
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Herpesvirus DNA Is Consistently Detected in Lungs of Patients with Idiopathic Pulmonary Fibrosis

TLDR
Immunohistochemistry for EBV or HHV-8 antigen showed viral antigen primarily in airway epithelial cells, supporting the concept that a herpesvirus could be a source of chronic antigenic stimulation in IPF.
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Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE.

TLDR
There was a linear relationship between the net quantities of PGD2 generated and of histamine secreted from dispersed human pulmonary cells when the number of mast cells was varied but the total number of cells was held constant, indicating that it is the numberof mast cells participating in IgE-dependent activation, rather than total mast cell number, that determines PGD 2 generation.
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Clinical experience over 48 years with pheochromocytoma.

TLDR
It is suggested that patients with extraadrenal pheochromocytomas have the same risk of malignancy and the same overall survival as patients with adrenal p heochromocrytomas.
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Salt–sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor

TLDR
Data demonstrate that the EP2 receptor mediates arterial dilatation, salt–sensitive hypertension, and also plays an essential part in female fertility, as demonstrated in mice created with targeted disruption of this gene.
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Tolerance to the humoral and hemodynamic effects of caffeine in man.

TLDR
Near complete tolerance, in terms of both humoral and hemodynamic variables, developed over the first 1-4 d of caffeine, and no long-term effects of caffeine on blood pressure, heart rate, plasma renin activity, plasma catecholamines, or urinary catechols could be demonstrated.
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New insights into the mechanism of action of acetaminophen: Its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H2 synthases

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Clinical implications of prostaglandin and thromboxane A2 formation (1).

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