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Individualization of phenytoin dosage regimens
Two methods for arriving at optimum, individual phenytoin dosage regimens have been evaluated in 12 patients. (1) Individual Michaelis‐Menten pharmacokinetic parameters for phenytoin were estimatedExpand
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Food, splanchnic blood flow, and bioavailability of drugs subject to first‐pass metabolism
There has been considerable interest in the past fifteen years in determining the influence of food and diet on gastrointestinal drug absorption. Welling21 has recently presented a comprehensive andExpand
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Free Drug Concentration Monitoring in Clinical Practice
SummaryRecent advances in techniques to determine free drug concentrations have lead to a substantial increase in the monitoring of this parameter in clinical practice. The majority of drug bindingExpand
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Transdermal application of lovastatin to rats causes profound increases in bone formation and plasma concentrations
IntroductionStatins are drugs that inhibit HMG Co-A reductase and have been shown to enhance bone formation in vitro and in vivo in rodents. However, the statins currently used forExpand
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The pharmacokinetics of meperidine in acute trauma patients.
Traumatic injury has the potential to alter the hepatic clearance and hence the efficacy and toxicity of drugs by a variety of mechanisms. These include changes in hepatic microsomal enzyme activity,Expand
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Factors Affecting Quinidine Protein Binding in Humans
The free (unbound) concentration of drug in plasma is often an important determinant of pharmacological and toxicological effects. Unfortunately, studies examining the factors influencing the freeExpand
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Indocyanine green: pharmacokinetics in the rabbit and relevant studies of its stability and purity.
The plasma concentration-time profile of indocyanine green (1) in the rabbit was determined by spectrophotometric and high-performance liquid chromatographic (HPLC) analysis following doses of 5 orExpand
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Free drug concentration monitoring in clinical practice. Rationale and current status.
Recent advances in techniques to determine free drug concentrations have lead to a substantial increase in the monitoring of this parameter in clinical practice. The majority of drug binding toExpand
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The Hepatic First‐Pass Metabolism of Problematic Drugs
The first‐pass hepatic metabolism of a number of important therapeutic agents is inconsistent with traditional models that assume that the hepatic extraction ratio of a drug is constant in eachExpand
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Alpha1‐acid glycoprotein concentration and protein binding in trauma
α1‐Acid glycoprotein (AAG) concentrations were measured every 2 to 3 days in eight trauma patients and seven healthy subjects for approximately 3 wk. Mean AAG concentrations in the trauma patientsExpand
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