• Publications
  • Influence
ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: A report of the American College of Cardiology/American Heart
TLDR
This guideline is pleased to have this guideline developed in conjunction with the European Society of Cardiology (ESC) and to have been selected from all 3 organizations to examine subject-specific data and write guidelines. Expand
The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.
TLDR
It is demonstrated that P-glycoprotein limits the oral bioavailability and penetration of these agents into the brain and raises the possibility that higher HIV-1 protease inhibitor concentrations may be obtained by targeted pharmacologic inhibition of P- glycoprotein transport activity. Expand
Estimation of the warfarin dose with clinical and pharmacogenetic data.
TLDR
The use of a pharmacogenetic algorithm for estimating the appropriate initial dose of warfarin produces recommendations that are significantly closer to the required stable therapeutic dose than those derived from a clinical algorithm or a fixed-dose approach. Expand
Cardiac ion channels.
TLDR
This review discusses new tools and how their application to the problem of arrhythmias is generating new mechanistic insights to identify patients at risk for this condition and developing improved antiarrhythmic therapies. Expand
Development of a Large‐Scale De‐Identified DNA Biobank to Enable Personalized Medicine
TLDR
A “opt‐out” model was implemented after significant review and revision to develop a DNA biobank linked to phenotypic data derived from an electronic medical record (EMR) system. Expand
Fulminant Myocarditis with Combination Immune Checkpoint Blockade.
TLDR
Patients with melanoma in whom fatal myocarditis developed after treatment with ipilimumab and nivolumab were having a rare, potentially fatal, T-cell-driven drug reaction, according to Pharmacovigilance studies. Expand
Genetic determinants of response to warfarin during initial anticoagulation.
TLDR
Initial variability in the INR response to warfarin was more strongly associated with genetic variability inThe pharmacologic target of warfarIn, VKORC1, than with CYP2C9, and both of these genotypes had a significant influence on the required warfarins after the first 2 weeks of therapy. Expand
Interrelationship Between Substrates and Inhibitors of Human CYP3A and P-Glycoprotein
TLDR
The results indicate that the overlap in substrate specificities of CYP3A and P-gp appears to be fortuitous rather than indicative of a more fundamental relationship. Expand
Clinical practice. Long-QT syndrome.
  • D. Roden
  • Medicine
  • The New England journal of medicine
  • 10 January 2008
TLDR
After a 13-year-old girl dies suddenly while playing basketball, her family comes to the clinic for medical evaluation, and the family history is notable for recurrent syncope in the maternal grandmother's female relatives. Expand
Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data
TLDR
The first large-scale application of the phenome-wide association study (PheWAS) paradigm within electronic medical records (EMRs) is reported, an unbiased approach to replication and discovery that interrogates relationships between targeted genotypes and multiple phenotypes in EMR-based cohorts. Expand
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