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ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: A report of the American College of Cardiology/American Heart…
This guideline is pleased to have this guideline developed in conjunction with the European Society of Cardiology (ESC) and to have been selected from all 3 organizations to examine subject-specific data and write guidelines.
The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.
It is demonstrated that P-glycoprotein limits the oral bioavailability and penetration of these agents into the brain and raises the possibility that higher HIV-1 protease inhibitor concentrations may be obtained by targeted pharmacologic inhibition of P- glycoprotein transport activity.
Fulminant Myocarditis with Combination Immune Checkpoint Blockade.
- Douglas B. Johnson, J. Balko, J. Moslehi
- Medicine, BiologyNew England Journal of Medicine
- 2 November 2016
Patients with melanoma in whom fatal myocarditis developed after treatment with ipilimumab and nivolumab were having a rare, potentially fatal, T-cell-driven drug reaction, according to Pharmacovigilance studies.
Estimation of the warfarin dose with clinical and pharmacogenetic data.
The use of a pharmacogenetic algorithm for estimating the appropriate initial dose of warfarin produces recommendations that are significantly closer to the required stable therapeutic dose than those derived from a clinical algorithm or a fixed-dose approach.
Cardiac ion channels.
This review discusses new tools and how their application to the problem of arrhythmias is generating new mechanistic insights to identify patients at risk for this condition and developing improved antiarrhythmic therapies.
Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data
The first large-scale application of the phenome-wide association study (PheWAS) paradigm within electronic medical records (EMRs) is reported, an unbiased approach to replication and discovery that interrogates relationships between targeted genotypes and multiple phenotypes in EMR-based cohorts.
Genetic determinants of response to warfarin during initial anticoagulation.
Initial variability in the INR response to warfarin was more strongly associated with genetic variability inThe pharmacologic target of warfarIn, VKORC1, than with CYP2C9, and both of these genotypes had a significant influence on the required warfarins after the first 2 weeks of therapy.
Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation.
Cardiac arrest due to torsade de pointes (TdP) in the acquired form of drug-induced long-QT syndrome (LQTS) is a rare but potentially catastrophic event in hospital settings. Administration of a…
A structural variation reference for medical and population genetics
A large empirical assessment of sequence-resolved structural variants from 14,891 genomes across diverse global populations in the Genome Aggregation Database (gnomAD) provides a reference map for disease-association studies, population genetics, and diagnostic screening.
Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans
It is discovered that flecainide prevents arrhythmias in a mouse model of CPVT by inhibiting cardiac ryanodine receptor–mediated Ca2+ release and thereby directly targeting the underlying molecular defect.