• Publications
  • Influence
The FDA critical path initiative and its influence on new drug development.
Societal expectations about drug safety and efficacy are rising while productivity in the pharmaceutical industry is falling. In 2004, the US Food and Drug Administration introduced the Critical PathExpand
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Drug-induced QT prolongation in women during the menstrual cycle.
CONTEXT Women have a higher incidence of torsades de pointes than men, but it is not known if the risk of drug-induced torsades de pointes varies during the menstrual cycle. OBJECTIVES To determineExpand
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Cardiac actions of antihistamines.
  • R. Woosley
  • Biology, Medicine
  • Annual review of pharmacology and toxicology
  • 1996
Two of the nonsedating antihistaminic drugs, terfenadine and astemizole, have recently been recognized in rare cases to induce the syndrome of torsades de pointes, i.e. QT interval prolongation andExpand
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Mechanism of the cardiotoxic actions of terfenadine.
OBJECTIVES AND METHODS To gain insight into possible mechanisms of and predisposing factors for torsades de pointes during terfenadine therapy, spontaneous reports in the US Food and DrugExpand
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Inappropriate prescribing for elderly Americans in a large outpatient population.
BACKGROUND We sought to determine the extent of potentially inappropriate outpatient prescribing for elderly patients, as defined by the Beers revised list of drugs to be avoided in elderlyExpand
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Tolerance to the humoral and hemodynamic effects of caffeine in man.
Acute caffeine in subjects who do not normally ingest methylxanthines leads to increases in blood pressure, heart rate, plasma epinephrine, plasma norepinephrine, plasma renin activity, and urinaryExpand
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Sex hormones prolong the QT interval and downregulate potassium channel expression in the rabbit heart.
BACKGROUND Sex hormones are known to exert direct and indirect effects on cardiovascular function, but their effects on cardiac repolarization have not been elucidated. The repolarization phase ofExpand
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Incidence and clinical features of the quinidine-associated long QT syndrome: implications for patient care.
Quinidine therapy is one of the most common causes of the acquired long QT syndrome and torsade de pointes. In reviewing clinical data in 24 patients with the quinidine-associated long QT syndrome,Expand
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Polymorphism of propafenone metabolism and disposition in man: clinical and pharmacokinetic consequences.
The relationship between debrisoquine metabolic phenotype and the pharmacokinetics and pharmacodynamics of propafenone was studied in 28 patients with chronic ventricular arrhythmias (22 extensiveExpand
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Gender difference in the cycle length-dependent QT and potassium currents in rabbits.
Women are known to have a longer electrocardiographic Q-T than men, which may contribute to their being at greater risk of developing drug-induced polymorphic ventricular arrhythmias. However, littleExpand
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