Voltage-Gated Sodium Channel Blockers

A series of chalcones of thiazole and thiazolidinone (3a–3j) were synthesized, characterized and evaluated for anticonvulsant… (More)

Voltage-gated sodium channels play a key role in the transmission of sensory information about the status of organs in the… (More)

Voltage-gated sodium channels (VGSCs), which are widely distributed in the excitable cells, are the primary mediators of… (More)

Recent findings showing a relation between mutations in the Na(V)1.7 channel in humans and altered pain sensation has contributed… (More)

Blocking of certain sodium channels is considered to be an attractive mechanism to treat chronic pain conditions. Phenyl… (More)

Hermitamides A and B are lipopeptides isolated from a Papau New Guinea collection of the marine cyanobacterium Lyngbya majuscula… (More)

Neuronal sodium channels blockers interfere with ion flux and have been used for managing neuropathic pain, epilepsy, and… (More)

Analogs of the previously reported voltage gated sodium channel blocker CDA54 were prepared in which one of the amide functions… (More)

A series of novel isoxazole voltage gated sodium channel blockers have been synthesized and evaluated. Substitutions on the… (More)

1. Intracellular current- and voltage-clamp recordings were carried out in CA3 pyramidal neurons from hippocampal slices of adult… (More)