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Encainide

Known as: Encainide [Chemical/Ingredient], 4-Methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide, Benzamide, 4-methoxy-N-(2-(2-(1-methyl-2-piperidinyl)ethyl)phenyl)-, (+-)- 
One of the ANTI-ARRHYTHMIA AGENTS, it blocks VOLTAGE-GATED SODIUM CHANNELS and slows conduction within the His-Purkinje system and MYOCARDIUM.
National Institutes of Health

Related topics

Related topics

15 relations

Broader (2)

Anti-Arrhythmia AgentsVoltage-Gated Sodium Channel Blockers
Drug AllergyEncainide HydrochlorideHeart BlockIn Blood

Narrower (2)

EnkaidMJ-9067

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1990
Highly Cited
1990
Clinical approach to paroxysmal atrial fibrillation
In addition to the role of the electrophysiological substrate, paroxysmal atrial fibrillation depends on the modulation of the… 
Review
1990
Review
1990
Advantages of beta blockers versus antiarrhythmic agents and calcium antagonists in secondary prevention after myocardial infarction.
1988
1988
Antiarrhythmic activity, electrocardiographic effects and pharmacokinetics of the encainide metabolites O-desmethyl encainide and 3-methoxy-O-desmethyl encainide in man.
Although encainide is an effective antiarrhythmic agent, plasma concentrations and pharmacologic effects are not well correlated… 
Review
1987
Review
1987
Pharmacokinetics and pharmacodynamics of antiarrhythmic agents in patients with congestive heart failure.
Highly Cited
1986
Highly Cited
1986
Effects of encainide and its metabolites on energy requirements for defibrillation.
Encainide, a class IC antiarrhythmic agent, has been associated with proarrhythmic responses of ventricular tachycardia and… 
Highly Cited
1986
Highly Cited
1986
Co‐inheritance of the polymorphic metabolism of encainide and debrisoquin
O‐demethylation of the investigational antiarrhythmic encainide was found to be correlated with the genetically determined… 
Review
1986
Review
1986
Effects of congestive heart failure on the pharmacokinetics and pharmacodynamics of antiarrhythmic agents.
Highly Cited
1983
Highly Cited
1983
Resting and Rate‐Dependent Depression of Maximum Rate of Depolarisation (Vmax) in Guinea Pig Ventricular Action Potentials by Mexiletine, Disopyramide, and Encainide
The influence of stimulation rate on the ability of mexiletine, disopyramide. and encainide to depress the maximum rate of… 
Highly Cited
1982
Highly Cited
1982
Metabolite cumulation during long‐term oral encainide administration
Cumulation of encainide and its major metabolites, O‐demethylencainide (ODE), 3‐methoxy‐ODE (MODE), and N‐demethylencainide (NDE… 
Highly Cited
1981
Highly Cited
1981
Antiarrhythmic Efficacy of Encainide in Patients with Refractory Recurrent Ventricular Tachycardia
Encainide is a new agent for treating ventricular arrhythmias. We attempted long-term oral therapy with encainide in 38 patients… 
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