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Encainide
Known as:
Encainide [Chemical/Ingredient]
, 4-Methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide
, Benzamide, 4-methoxy-N-(2-(2-(1-methyl-2-piperidinyl)ethyl)phenyl)-, (+-)-
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One of the ANTI-ARRHYTHMIA AGENTS, it blocks VOLTAGE-GATED SODIUM CHANNELS and slows conduction within the His-Purkinje system and MYOCARDIUM.
National Institutes of Health
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Related topics
Related topics
15 relations
Broader (2)
Anti-Arrhythmia Agents
Voltage-Gated Sodium Channel Blockers
Drug Allergy
Encainide Hydrochloride
Heart Block
In Blood
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Narrower (2)
Enkaid
MJ-9067
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1990
Highly Cited
1990
Clinical approach to paroxysmal atrial fibrillation
P. Coumel
Clinical Cardiology
1990
Corpus ID: 20022129
In addition to the role of the electrophysiological substrate, paroxysmal atrial fibrillation depends on the modulation of the…
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Review
1990
Review
1990
Advantages of beta blockers versus antiarrhythmic agents and calcium antagonists in secondary prevention after myocardial infarction.
Bramahn . Singh
,
Bramahn . Singh
American Journal of Cardiology
1990
Corpus ID: 40747530
1988
1988
Antiarrhythmic activity, electrocardiographic effects and pharmacokinetics of the encainide metabolites O-desmethyl encainide and 3-methoxy-O-desmethyl encainide in man.
J. Barbey
,
K. Thompson
,
D. Echt
,
R. Woosley
,
D. Roden
Circulation
1988
Corpus ID: 8919009
Although encainide is an effective antiarrhythmic agent, plasma concentrations and pharmacologic effects are not well correlated…
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Highly Cited
1986
Highly Cited
1986
Effects of encainide and its metabolites on energy requirements for defibrillation.
E. Fain
,
P. Dorian
,
J. Davy
,
R. Kates
,
R. Winkle
Circulation
1986
Corpus ID: 5853756
Encainide, a class IC antiarrhythmic agent, has been associated with proarrhythmic responses of ventricular tachycardia and…
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Highly Cited
1986
Highly Cited
1986
Co‐inheritance of the polymorphic metabolism of encainide and debrisoquin
R. Woosley
,
D. Roden
,
+4 authors
G. Wilkinson
Clinical pharmacology and therapy
1986
Corpus ID: 26801235
O‐demethylation of the investigational antiarrhythmic encainide was found to be correlated with the genetically determined…
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Review
1986
Review
1986
Effects of congestive heart failure on the pharmacokinetics and pharmacodynamics of antiarrhythmic agents.
R. Woosley
,
D. Echt
,
D. Roden
American Journal of Cardiology
1986
Corpus ID: 22744703
Highly Cited
1983
Highly Cited
1983
Resting and Rate‐Dependent Depression of Maximum Rate of Depolarisation (Vmax) in Guinea Pig Ventricular Action Potentials by Mexiletine, Disopyramide, and Encainide
T. Campbell
Journal of Cardiovascular Pharmacology
1983
Corpus ID: 34864308
The influence of stimulation rate on the ability of mexiletine, disopyramide. and encainide to depress the maximum rate of…
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1983
1983
Electrophysiologic actions of O-demethyl encainide: an active metabolite.
H. Duff
,
A. K. Dawson
,
D. Roden
,
J. Oates
,
R. Smith
,
R. Woosley
Circulation
1983
Corpus ID: 6599121
Differences between the electrophysiologic actions of the antiarrhythmic agent encainide have been reported after short-term…
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Highly Cited
1982
Highly Cited
1982
Metabolite cumulation during long‐term oral encainide administration
R. Kates
,
Donald C. Harrison
,
R. Winkle
Clinical pharmacology and therapy
1982
Corpus ID: 43904017
Cumulation of encainide and its major metabolites, O‐demethylencainide (ODE), 3‐methoxy‐ODE (MODE), and N‐demethylencainide (NDE…
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Highly Cited
1981
Highly Cited
1981
Antiarrhythmic Efficacy of Encainide in Patients with Refractory Recurrent Ventricular Tachycardia
J. Mason
,
F. Peters
Circulation
1981
Corpus ID: 9310554
Encainide is a new agent for treating ventricular arrhythmias. We attempted long-term oral therapy with encainide in 38 patients…
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