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Encainide

Known as: Encainide [Chemical/Ingredient], 4-Methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide, Benzamide, 4-methoxy-N-(2-(2-(1-methyl-2-piperidinyl)ethyl)phenyl)-, (+-)- 
One of the ANTI-ARRHYTHMIA AGENTS, it blocks VOLTAGE-GATED SODIUM CHANNELS and slows conduction within the His-Purkinje system and MYOCARDIUM.
National Institutes of Health

Related topics

Related topics

15 relations

Broader (2)

Anti-Arrhythmia AgentsVoltage-Gated Sodium Channel Blockers
Drug AllergyEncainide HydrochlorideHeart BlockIn Blood

Narrower (2)

EnkaidMJ-9067

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1986
1986
Comparative antiarrhythmic actions of encainide and its major metabolites.
The local anesthetic, antiarrhythmic, and acute toxicologic properties of the O-demethyl (ODE), 3-methoxy-O-demethyl (MODE) and N… 
1985
1985
The Effects of Encainide and Its Major Metabolites,O -Demethyl Encainide and 3-Methoxy-O -Demethyl Encainide, on Experimental Cardiac Arrhythmias in Dogs
Summary: Encainide (E) is a class I antiarrhythmic agent which is metabolised in humans, with the formation in the majority of… 
1984
1984
Electrophysiological Effects of Encainide (MJ9067) on Canine Subendocardial Purkinje Fibers Surviving Infarction
The electrophysiological effects of encainide (MJ9067) on canine subendocardial Purkinje fibers surviving infarction were… 
1984
1984
Electrophysiology of O‐Demethyl Encainide in a Canine Model of Sustained Ventricular Tachycardia
The antiarrhythmic agent encainide produces marked suppression of ventricular arrhythmias in most patients. However, in some with… 
Highly Cited
1983
Highly Cited
1983
Resting and Rate‐Dependent Depression of Maximum Rate of Depolarisation (Vmax) in Guinea Pig Ventricular Action Potentials by Mexiletine, Disopyramide, and Encainide
The influence of stimulation rate on the ability of mexiletine, disopyramide. and encainide to depress the maximum rate of… 
1983
1983
Electrophysiologic actions of O-demethyl encainide: an active metabolite.
Differences between the electrophysiologic actions of the antiarrhythmic agent encainide have been reported after short-term… 
1982
1982
Antiarrhythmic Drug Combinations in the Treatment of Ventricular Tachycardia Efficacy and Electrophysiologic Effects
Combinations of antiarrhythmic drugs are frequently used to treat refractory ventricular tachycardia (VT), but few scientific… 
Highly Cited
1981
Highly Cited
1981
Antiarrhythmic Efficacy of Encainide in Patients with Refractory Recurrent Ventricular Tachycardia
Encainide is a new agent for treating ventricular arrhythmias. We attempted long-term oral therapy with encainide in 38 patients… 
1981
1981
Electrophysiologic Effects of Encainide Following Acute Coronary Occlusion in Dogs
Summary Encainide, a benzanilide derivative, is a local anesthetic antiarrhythmic drug. To determine its effects on infarcted and… 
1980
1980
Effects of Encainide (MJ9067) on the Ventricular Fibrillation Threshold in Anesthetized Dogs
The right ventricular epicardial ventricular fibrillation threshold (VFT) was determined during paced supraventricular rhythm… 
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