• Publications
  • Influence
The toxicogenomic multiverse: convergent recruitment of proteins into animal venoms.
TLDR
A number of overarching structural, functional, and evolutionary generalities of the protein families from which these toxins have been frequently recruited are discussed and a revised and expanded working definition for venom is proposed.
Distinct and essential morphogenic functions for wall‐ and lipo‐teichoic acids in Bacillus subtilis
TLDR
It is shown that LTA is needed for divalent cation homoeostasis and that its absence has severe effects on cell morphogenesis and cell division and the crystal structure of the extracytoplasmic part of LtaS reveals a phosphorylated threonine residue, which provides clues about the catalytic mechanism and identifies the active site of the enzyme.
Characterization of the Sporulation Initiation Pathway of Clostridium difficile and Its Role in Toxin Production
TLDR
Spo0A was directly phosphorylated by a putative sporulation-associated kinase, supporting the hypothesis that sporulation initiation in C. difficile is controlled by a two-component signal transduction system rather than a multicomponent phosphorelay.
A widespread family of bacterial cell wall assembly proteins
TLDR
The widespread LytR–Cps2A–Psr (LCP) protein family, of previously unknown function, is identified as novel enzymes required for AP synthesis, suggesting that they carry out the final step of transferring APs from their lipid‐linked precursor to cell wall peptidoglycan (PG).
Molecular Architecture of the "Stressosome," a Signal Integration and Transduction Hub
TLDR
It is suggested that the different sensory extensions respond to different signals, whereas the conserved domains in the core integrate the varied signals, and the architecture of the stressosome provides the potential for cooperativity.
Ichthyotoxicity of Chattonella marina (Raphidophyceae) to damselfish (Acanthochromis polycanthus): the synergistic role of reactive oxygen species and free fatty acids
TLDR
It is concluded that the enhancement of ichthyotoxicity of EPA in the presence of superoxide can account for the high C. marina fish killing potential.
A supramolecular complex in the environmental stress signalling pathway of Bacillus subtilis
TLDR
It is demonstrated that RsbS alone cannot act as an alternative partner for RsbT, but instead requires the presence of £bR to create a high molecular mass RsbR:RsbS complex (∼‼ 1 MDa) able to capture £bT.
Ciguatera: Australian perspectives on a global problem.
  • R. Lewis
  • Medicine
    Toxicon : official journal of the International…
  • 1 December 2006
TLDR
Progress in the understanding of ciguatera from an Australian perspective is examined, especially the laboratory-based research into the problem that was initiated by the late "Bob" Endean at the University of Queensland.
Therapeutic potential of venom peptides
TLDR
The pharmacology of venom peptides is surveyed and their therapeutic prospects are assessed for the treatment of pain, diabetes, multiple sclerosis and cardiovascular diseases are assessed.
AChBP-targeted α-conotoxin correlates distinct binding orientations with nAChR subtype selectivity
TLDR
A binding assay based on acetylcholine‐binding protein (AChBP) is used to discover a novel α‐conotoxin (α‐TxIA) in the venom of Conus textile, establishing a new pharmacophore for the design of novel subtype‐selective ligands with therapeutic potential in nAChR‐related diseases.
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