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Dopamine in the treatment of hypotension and shock.
TLDR
Attempts to achieve myocardial stimulation without vasoconstriction have centered on the use of sympathomimetic amines with predominant beta-adrenergic activity (isoproterenol,3 or epinephrine4) or on the conjoint use of alpha-adRenergic blocking agents with amines possessing both alpha and beta activity (norepinephrine5 or metaraminol). Expand
Effects of dopamine on renal function and hemodynamics in the dog.
TLDR
It was concluded that the changes in urine formation in the dog resembled those previously observed in man and were not dependent upon systemic hemodynamic changes. Expand
Evaluation of Etidocaine, A New Local Anesthetic Agent, with a Modified Bilateral Ulnar-nerve-block Technique
Etidocaine, a new local anesthetic, was evaluated in a double-blind study using ulnar-nerve block. In addition, electromyography for the assessment of peripheral nerve motor blockade wasExpand
Kinetics of the oral antiarrhythmie lidocaine congener, tocainide
TLDR
Tocainide, a primary amine analogue of lidocaine, is effective against some experimental and clinical arrhythmias and bioavailability approached 100%. Expand
Tocainide conjugation in humans: novel biotransformation pathway for a primary amine.
TLDR
The metabolism of tocainide, an experimental antiarrhythmic drug, was studied in humans and a compound identified as 3-(2,6-xylyl)-5-methylhydantoin was derived from the same metabolite that formed the additional toc Cainide after acid or beta-glucuronidase treatment. Expand
Assay of tocainide in blood by high-pressure liquid chromatography.
TLDR
A sensitive, specific, high-pressure liquid chromatographic assay for the determination of tocainide in whole blood was tested on samples from emergency protocol patients and was also found suitable for single-dose pharmacokinetic studies. Expand
Blood levels of lidocaine following subcutaneous administration prior to cardiac catheterization.
TLDR
The results indicate that no alteration of hemodynamic function should occur following the use of lidocaine subcutaneously for infiltration anesthesia in preparation for cardiac catheterization studies, and one should not anticipate any degree of ventricular antiarrhythmic activity due to the low levels of lidOCaine achieved. Expand
Antiarrhythmic Effectiveness of Intramuscular Lidocaine: Influence of Different Injection Sites
TLDR
It appears desirable to develop a rapidly effective oral antiarrhythmic drug or a safe parenteral agent which can be administered by either medical or paramedical personnel or perhaps by the patient himself who is at high risk of acute myocardial infarction. Expand
Absorption kinetics of procainamide in humans.
TLDR
Plasma procainamide concentrations following the administration of 500 mg of Procainamide hydrochloride via intravenous infusion, conventional capsules, and sustained-release tablets were compared in 11 healthy male volunteers to suggest that absorption was a first-order process. Expand
Effect of upright tilt on the phases of the cardiac cycle in normal subjects.
TLDR
The sensitivity of non-invasive techniques to the stress of tilting provides a basis for their wider application in the evaluation of cardiocirculatory status. Expand
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