Thyroid Hormone Receptor Alpha-1

Known as: ERBA-Alpha Protein, Nuclear Receptor Subfamily 1 Group A Member 1, EAR-7 
Thyroid hormone receptor alpha (490 aa, ~55 kDa) is encoded by the human THRA gene. This protein is involved in thyroid hormone-mediated… (More)
National Institutes of Health

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Biologic DevelopmentCell Differentiation processCell NucleusCell Proliferation
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Thyroid hormone receptor alpha

Papers overview

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Highly Cited
2012
Highly Cited
2012
A mutation in the thyroid hormone receptor alpha gene.
Thyroid hormones exert their effects through alpha (TRα1) and beta (TRβ1 and TRβ2) receptors. Here we describe a child with… (More)
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2010
2010
Increased depressive behaviour in mice harboring the mutant thyroid hormone receptor alpha 1
Clinical evidence indicates that hypothyroidism contributes to mood disorders. The present study tested if the mutant thyroid… (More)
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Highly Cited
2007
Highly Cited
2007
Systems metabolic engineering of Escherichia coli for L-threonine production
Amino-acid producers have traditionally been developed by repeated random mutagenesis owing to the difficulty in rationally… (More)
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2004
2004
Aberrant maturation of astrocytes in thyroid hormone receptor alpha 1 knockout mice reveals an interplay between thyroid hormone receptor isoforms.
Although the effects of thyroid hormones on the development of neurons and oligodendrocytes are well documented, less is known… (More)
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Highly Cited
2003
Highly Cited
2003
A thyroid hormone receptor alpha gene mutation (P398H) is associated with visceral adiposity and impaired catecholamine-stimulated lipolysis in mice.
Thyroid hormone has profound effects on metabolic homeostasis, regulating both lipogenesis and lipolysis, primarily by modulating… (More)
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Highly Cited
2002
Highly Cited
2002
Deletion of the thyroid hormone receptor alpha 1 prevents the structural alterations of the cerebellum induced by hypothyroidism.
Thyroid hormone (T3) controls critical aspects of cerebellar development, such as migration of postmitotic granule cells and… (More)
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Highly Cited
2002
Highly Cited
2002
Normal timing of oligodendrocyte development depends on thyroid hormone receptor alpha 1 (TRalpha1).
The timing of oligodendrocyte development is regulated by thyroid hormone (TH) in vitro and in vivo, but it is still uncertain… (More)
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Highly Cited
1998
Highly Cited
1998
Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor alpha 1.
Thyroid hormone, acting through several nuclear hormone receptors, plays important roles in thermogenesis, lipogenesis and… (More)
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Highly Cited
1998
Highly Cited
1998
The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion.
Cognate cDNAs are described for 2 of the 10 thyroid hormone receptor-associated proteins (TRAPs) that are immunopurified with… (More)
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Highly Cited
1989
Highly Cited
1989
Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus.
Two erbA homologs, termed ear-1 and ear-7, are present in the human genome on chromosome 17. The two genes reside in the same… (More)
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