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Antiinflammatory roles of peroxisome proliferator-activated receptor gamma in human alveolar macrophages.
- K. Asada, S. Sasaki, T. Suda, K. Chida, Hirotoshi Nakamura
- Biology, MedicineAmerican journal of respiratory and critical care…
- 15 January 2004
Data indicate that PPARgamma expressed by AMs play an antiinflammatory role through inhibiting cytokine production and increasing their CD36 expression together with the enhanced phagocytosis of apoptotic neutrophils, which is an essential process for the resolution of inflammation.
1,25-dihydroxyvitamin D3 and its receptor inhibit the chenodeoxycholic acid-dependent transactivation by farnesoid X receptor.
- Y. Honjo, S. Sasaki, Yoshimasa Kobayashi, H. Misawa, Hirotoshi Nakamura
- Biology, MedicineThe Journal of endocrinology
- 1 March 2006
D3 and its receptor (VDR) inhibited the transactivation of all four reporter constructs that are enhanced by CDCA/FXR and revealed that its ligand-bindingdomain (LBD) is responsible for the repression and the DNA-binding domain (DBD) is dispensable.
Essential role of GATA2 in the negative regulation of thyrotropin beta gene by thyroid hormone and its receptors.
- A. Matsushita, S. Sasaki, +6 authors Hirotoshi Nakamura
- Biology, MedicineMolecular endocrinology
- 1 April 2007
GATA2 is the major transcriptional activator of the TSHbeta gene, the putative NRE is not required, TR-DNA-binding domain directly interacts with the Zn finger region of GATA2, and histone deacetylation and TRAP220 dissociation are important.
Functions of PIT1 in GATA2-dependent transactivation of the thyrotropin beta promoter.
- Y. Kashiwabara, S. Sasaki, +9 authors Hirotoshi Nakamura
- Biology, MedicineJournal of molecular endocrinology
- 5 December 2008
This study indicates that major activator for the TSHbeta promoter is GATA2 and that PIT1 protects the function of GATA1 from the inhibition by SR-binding protein.
High incidence of thyroid cancer in focal thyroid incidentaloma detected by 18F-fluorodeoxyglucose [corrected] positron emission tomography in relatively young healthy subjects: results of 3-year…
When closely examined, focal thyroid PET incidentaloma in relatively young healthy adults has a high probability of malignancy and repeated FDG-PET to follow up patients with thyroid nodules is ineffective.
Inappropriate elevation of serum thyrotropin levels in patients treated with axitinib.
- K. Ohba, T. Takayama, +5 authors Hirotoshi Nakamura
- MedicineThyroid : official journal of the American…
- 27 March 2013
This is the first study to report an inappropriate elevation of serum TSH levels in patients treating with axitinib, and a similar tendency, though weaker, was observed in some patients treated with sunit inib or sorafenib.
Erratum: High incidence of thyroid cancer in focal thyroid incidentaloma detected by 18F-fluorodexyglucose positron emission tomography in relatively young healthy subjects: results of 3-year…
Immunohistochemical localization of nuclear 3,5,3'-triiodothyronine receptor proteins in rat tissues studied with antiserum against C-ERB A/T3 receptor.
It is shown that NT3R distributes selectively in certain types of cells in many tissues and that the content ofNT3R proteins seems to correlate with the concentration of c-erb A mRNA alpha 1 and beta among many organs.
Beta-catenin/Tcf-1-mediated transactivation of cyclin D1 promoter is negatively regulated by thyroid hormone.
- H. Natsume, S. Sasaki, +8 authors Hirotoshi Nakamura
- Biology, MedicineBiochemical and biophysical research…
- 19 September 2003
Results indicate that the T3-bound TR inhibits the transcription of cyclin D1 through the Tcf/Lef-1 site, which is positively regulated by the Wnt-signaling pathway.
Thyroid-hormone-dependent negative regulation of thyrotropin beta gene by thyroid hormone receptors: study with a new experimental system using CV1 cells.
- Keiko Nakano, A. Matsushita, +4 authors Hirotoshi Nakamura
- Biology, MedicineThe Biochemical journal
- 1 March 2004
An assay system using non-pituitary CV1 cells and analyses using various receptor mutants revealed that the intact DNA-binding domain is crucial to the TSHbeta gene suppression, suggesting that co-activators and co-repressors are not necessarily essential, but are required for the full suppression of the T SHbeta gene.