D. Stéhelin

Publications233
h-index57
Citations12,524
Highly Influential Citations322
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DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA
TLDR
It is demonstrated here that the DNA of normal chicken cells contains nucleotide sequences closely related to at least a portion of the transforming gene(s) of ASV; in addition, similar sequences are widely distributed among DNA of avian species and that they have diverged roughly according to phylogenetic distances among the species.
Evolution of the nuclear receptor gene superfamily.
TLDR
A complex evolutionary history for nuclear receptor genes in which gene duplication events and swapping between domains of different origins took place is suggested.
Ligand binding was acquired during evolution of nuclear receptors.
TLDR
The results suggest that the ancestral NR was an orphan receptor that acquired ligand-binding ability during subsequent evolution, and that the present NR diversity arose from two waves of gene duplications.
Ancestry and diversity of the HMG box superfamily.
TLDR
By studying the extent of diversification of the HMG box superfamily, it is found that the speed of evolution was very different within the various groups of HMG-box containing factors.
Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene
TLDR
It is shown, by using RAG-2-deficient blasto-cyst complementation, that Ets-1 deficiency has dramatic, but different, effects on development and function of T- and B-lineage cells.
The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation
TLDR
The p68c-ets-1 protein cooperates with c-Fos and c-Jun (components of AP-1) for activation of transcription from the oncogene-responsive domain of the polyoma enhancer, indicating that combined activity of all three oncoproteins could be involved in the response of cells to growth stimuli.
A putative second cell-derived oncogene of the avian leukaemia retrovirus E26
TLDR
It is proposed that v-ets could be a new oncogene accounting for the additional transforming properties of E26, or potentiating the transforms properties of the v-myb oncogenic.
Erg proteins, transcription factors of the Ets family, form homo, heterodimers and ternary complexes via two distinct domains
TLDR
It is demonstrated that the Ergp55 protein isoform forms dimers with itself and with the two other isoforms, Ergp49 and Ergp38, and that Fli-1, Ets-2, Er81 and Pu-1 physically interact with Erg.
Characterization of quail Pax-6 (Pax-QNR) proteins expressed in the neuroretina.
TLDR
The Pax-QNR/Pax-6 gene can produce proteins with two DNA-binding domains as well as proteins containing only the DNA- binding homeodomain.
Molecular cloning of a novel widely expressed human 80 kDa 17 beta-hydroxysteroid dehydrogenase IV.
TLDR
Cloning of the cDNA of a novel human 17 beta-HSD IV and expression of its mRNA are described, finding sequence similarities shared by the two enzymes are similar to that of members of the short-chain alcohol dehydrogenase family.
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