• Publications
  • Influence
Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype
Genome analysis provides a greatly improved fish gene catalogue, including identifying key genes previously thought to be absent in fish, and reconstructs much of the evolutionary history of ancient and recent chromosome rearrangements leading to the modern human karyotype.
Overview of Nomenclature of Nuclear Receptors
The characterization of nuclear receptors and their associated proteins and the ligands that interact with them will remain a challenge to pharmacologists.
Principles for modulation of the nuclear receptor superfamily
This review provides a general overview of the mechanism of action of nuclear receptors and explores the various factors that are instrumental in modulating their pharmacology.
The genome of the model beetle and pest Tribolium castaneum
Tribolium castaneum is a member of the most species-rich eukaryotic order, a powerful model organism for the study of generalized insect development, and an important pest of stored agricultural
Evidence for two distinct functional glucocorticoid receptors in teleost fish.
Results indicate that these two GR sequences encode for two functionally distinct GRs acting as ligand-inducible transcription factors in rainbow trout.
Genome sequence of the metazoan plant-parasitic nematode Meloidogyne incognita
The draft genome sequence of the root-knot nematode Meloidogyne incognita, a biotrophic parasite of many crops, is reported, providing insights into the adaptations required by metazoans to successfully parasitize immunocompetent plants, and open the way for discovering new antiparasitic strategies.
From carrot to clinic: an overview of the retinoic acid signaling pathway
The origin and diversification of the retinoids pathway are discussed, which are important factors for understanding the evolution of ligand-specificity among retinoid receptors.
Molecular Characterization of Three Estrogen Receptor Forms in Zebrafish: Binding Characteristics, Transactivation Properties, and Tissue Distributions1
The cloning and characterization of three functional ER forms, zfERα, z fERβ1, and zf ERβ2, in the zebrafish provides a new perspective for understanding the mechanisms underlying estradiol actions in a vertebrate species commonly used for developmental studies.
Evolutionary genomics of nuclear receptors: from twenty-five ancestral genes to derived endocrine systems.
Notably, differential gene loss played an important role in the evolution of different nuclear receptor sets in bilaterian lineages and was also shaped by periods of gene duplication in vertebrates, as well as a lineage-specific duplication burst in nematodes.
DMRT1 expression during gonadal differentiation and spermatogenesis in the rainbow trout, Oncorhynchus mykiss.
Cloned a DMRT1 homologue in the rainbow trout showed that this gene is expressed during testicular differentiation, but not during ovarian differentiation, and new DM-domain homologous sequences in fish suggest that at least four different genes bearing 'DM-domain' (DMRT genes) exist in fish just as in all vertebrate genomes.