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Thromboxane-A Synthase

Known as: Thromboxane A2 Synthetase, (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A(2)-isomerase, Thromboxane-A Synthase [Chemical/Ingredient] 
An enzyme found predominantly in platelet microsomes. It catalyzes the conversion of PGG(2) and PGH(2) (prostaglandin endoperoxides) to thromboxane… 
National Institutes of Health

Related topics

Related topics

12 relations
In BloodProcess of secretionTBXAS1 geneThromboxanes

Broader (1)

Isomerase

Narrower (1)

RS 86328

Papers overview

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Highly Cited
2001
Highly Cited
2001
Cyclooxygenase inhibitors and the antiplatelet effects of aspirin.
BACKGROUND Patients with arthritis and vascular disease may receive both low-dose aspirin and other nonsteroidal antiinflammatory… 
Highly Cited
2001
Highly Cited
2001
Effects of cocoa powder and dark chocolate on LDL oxidative susceptibility and prostaglandin concentrations in humans.
BACKGROUND Flavonoids are polyphenolic compounds of plant origin with antioxidant effects. Flavonoids inhibit LDL oxidation and… 
Highly Cited
2000
Highly Cited
2000
Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation.
To examine the role of cyclooxygenase (COX) isozymes in prostaglandin formation and oxidant stress in inflammation, we… 
Highly Cited
1985
Highly Cited
1985
Pharmacological actions of SQ 29,548, a novel selective thromboxane antagonist.
SQ 29,548, [1S-[1 alpha,2 beta (5Z),3 beta,4 alpha]-7-[3-[[2-[(phenylamino) carbonyl]hydrazino]methyl]-7-oxabicyclo[2.2.1] hept-2… 
Highly Cited
1984
Highly Cited
1984
Prostaglandin I3 is formed in vivo in man after dietary eicosapentaenoic acid
Greenland Eskimos who live on a traditional marine diet rich in long chain ω3-polyunsaturated fatty acids have a low incidence of… 
Highly Cited
1981
Highly Cited
1981
Increased platelet thromboxane synthesis in diabetes mellitus.
Platelets obtained from some diabetic patients show enhanced in vitro platelet aggregation. This study sought to determine… 
Highly Cited
1981
Highly Cited
1981
Bovine endothelial cells in culture produce thromboxane as well as prostacyclin.
Bovine aortic endothelial and smooth muscle cells in culture were incubated with arachidonic acid or prostaglandin H2. The amount… 
Highly Cited
1980
Highly Cited
1980
Captopril-induced changes in prostaglandin production: relationship to vascular responses in normal man.
Captopril is a potent hypotensive agent whose efficacy has hitherto been attributed to its ability to alter either angiotensin II… 
Highly Cited
1977
Highly Cited
1977
Imidazole: a selective inhibitor of thromboxane synthetase.
Highly Cited
1976
Highly Cited
1976
Thromboxanes: selective biosynthesis and distinct biological properties.
The prostaglandin endoperoxide ring structure alone does not establish suitability as a substrate for thromboxane synthetase, but… 
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