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Thromboxane-A Synthase

Known as: Thromboxane A2 Synthetase, (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A(2)-isomerase, Thromboxane-A Synthase [Chemical/Ingredient] 
An enzyme found predominantly in platelet microsomes. It catalyzes the conversion of PGG(2) and PGH(2) (prostaglandin endoperoxides) to thromboxane… 
National Institutes of Health

Related topics

Related topics

12 relations
In BloodProcess of secretionTBXAS1 geneThromboxanes

Broader (1)

Isomerase

Narrower (1)

RS 86328

Papers overview

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Highly Cited
2000
Highly Cited
2000
Regulation of Prostaglandin Biosynthesis by Nitric Oxide Is Revealed by Targeted Deletion of Inducible Nitric-oxide Synthase*
We investigated the effects of targeted deletion of the inducible NO synthase (iNOS) gene on the formation of prostaglandins in… 
Highly Cited
1986
Highly Cited
1986
Increased thromboxane biosynthesis in a human preparation of platelet activation: biochemical and functional consequences of selective inhibition of thromboxane synthase.
Although thromboxane A2 is a potent platelet agonist and vasoconstrictor in vitro, our knowledge of its pathophysiologic… 
Highly Cited
1983
Highly Cited
1983
Arachidonic acid stimulates the formation of 1,2-diacylglycerol and phosphatidic acid in human platelets. Degree of phospholipase C activation correlates with protein phosphorylation, platelet shape…
Highly Cited
1982
Highly Cited
1982
ANTAGONISM OF THE THROMBOXANE‐SENSITIVE CONTRACTILE SYSTEMS OF THE RABBIT AORTA, DOG SAPHENOUS VEIN AND GUINEA‐PIG TRACHEA
1 The thromboxane‐sensitive contractile systems in spirally‐cut preparations of the rabbit aorta, dog saphenous vein and guinea… 
Highly Cited
1981
Highly Cited
1981
Vasoconstriction with thromboxane A2 induces ulceration of the gastric mucosa
Thromboxane A2 (TXA2) is formed from the fatty acid precursor, arachidonic acid (AA), by the sequential actions of the enzymes… 
Highly Cited
1980
Highly Cited
1980
Manipulation of platelet aggregation by prostaglandins and their fatty acid precursors: pharmacological basis for a therapeutic approach.
Highly Cited
1979
Highly Cited
1979
Peroxidase-dependent deactivation of prostacyclin synthetase.
A study of the enzymes of the arachidonic acid cascade revealed a high sensitivity of prostacyclin synthetase and a complete… 
Highly Cited
1977
Highly Cited
1977
A radioimmunoassay for thromboxane B2.
Highly Cited
1977
Highly Cited
1977
Solubilization and resolution of thromboxane synthesizing system from microsomes of bovine blood platelets.
Highly Cited
1966
Highly Cited
1966
Lipid Metabolism in Cultured Cells
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