Thromboxane-A Synthase

Known as: Thromboxane A2 Synthetase, (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A(2)-isomerase, Thromboxane-A Synthase [Chemical/Ingredient] 
An enzyme found predominantly in platelet microsomes. It catalyzes the conversion of PGG(2) and PGH(2) (prostaglandin endoperoxides) to thromboxane… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1976-2018
05010019762018

Papers overview

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Highly Cited
2010
Highly Cited
2010
Modern functional imaging techniques of the brain measure local hemodynamic responses evoked by neuronal activity. Capillary… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Incomplete inhibition of platelet thromboxane generation, as measured by elevated urinary 11-dehydro thromboxane B(2… (More)
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Highly Cited
2007
Highly Cited
2007
AIMS We sought to compare the results obtained from six major platelet function tests in the assessment of the prevalence of… (More)
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Highly Cited
2004
Highly Cited
2004
Production of thromboxane (TX) A2 and PG I2/prostacyclin (PGI2) is increased in patients with atherosclerosis. However, their… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND The role of eicosanoids, including leukotrienes (LTs) and prostaglandins (PGs), in chronic obstructive pulmonary… (More)
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Highly Cited
2002
Highly Cited
2002
Cyclooxygenase-2 (COX-2) action on the endocannabinoids, 2-arachidonylglycerol (2-AG) and anandamide (AEA), generates… (More)
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Highly Cited
2002
Highly Cited
2002
Cyclooxygenase-2 (COX-2) is expressed within neovascular structures that support many human cancers. Inhibition of COX-2 by… (More)
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Highly Cited
1995
Highly Cited
1995
BACKGROUND The L-arginine/nitric oxide pathway plays a key role in the regulation of arterial tone. Biosynthesis of nitric oxide… (More)
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Highly Cited
1986
Highly Cited
1986
To study the mechanism of decreased endothelium-dependent relaxations in spontaneously hypertensive rats (SHR), rings of thoracic… (More)
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Highly Cited
1979
Highly Cited
1979
Platelets enzymatically convert prostaglandin H(3) (PGH(3)) into thromboxane A(3). Both PGH(2) and thromboxane A(2) aggregate… (More)
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