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Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids.
Nitrate biosynthesis in man.
- L. Green, K. Ruiz de Luzuriaga, S. Tannenbaum
- MedicineProceedings of the National Academy of Sciences…
- 1 December 1981
Nitrate metabolism was investigated in long-term metabolic studies in healthy young men under conditions of constant low ingestion, and showed that the source of the excess nitrate in urine was the endogenous biosynthesis of nitrate, rather than the emptying of a body pool.
The chemistry of DNA damage from nitric oxide and peroxynitrite.
Arsenic Exposure Perturbs the Gut Microbiome and Its Metabolic Profile in Mice: An Integrated Metagenomics and Metabolomics Analysis
These findings may provide novel insights regarding perturbations of the gut microbiome and its functions as a potential new mechanism by which arsenic exposure leads to or exacerbates human diseases.
Reactive nitrogen species in the chemical biology of inflammation.
Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies
Protein retention ExM is described, a variant of ExM in which proteins are anchored to the swellable gel, allowing the use of conventional fluorescently labeled antibodies and streptavidin, and fluorescent proteins, for multicolor super-resolution imaging of cells and mammalian tissues on conventional microscopes.
DNA damage and mutation in human cells exposed to nitric oxide in vitro.
- T. Nguyen, D. Brunson, C. Crespi, B. W. Penman, J. Wishnok, S. Tannenbaum
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 April 1992
Experiments in which NO was added to intact human cells and to aerobic solutions of DNA, RNA, guanine, or adenine produced a 40- to 50-fold increase in hypoxanthine and xanthine in cellular DNA, which are believed to account for the mutagenicity of nitric oxide toward bacteria and mammalian cells.
A microscale in vitro physiological model of the liver: predictive screens for drug metabolism and enzyme induction.
A scalable microreactor system that fosters development of 3D-perfused micro-tissue units is described and it is shown that primary rat cells cultured in this system are substantially closer to native liver compared to cells cultured by other in vitro methods, as assessed by a broad spectrum of gene expression, protein expression and biochemical activity metrics.
Gender- and smoking-related bladder cancer risk.
The risk of bladder cancer in women who smoked was statistically significantly higher than that in men who smoked comparable numbers of cigarettes, and the slopes of the linear regression lines of the 3- and 4-ABP--hemoglobin adducts by cigarettes per day were statistically significantly steeper in women than in men.
The chemistry of the S-nitrosoglutathione/glutathione system.
- S. Singh, J. Wishnok, M. Keshive, W. Deen, S. Tannenbaum
- ChemistryProceedings of the National Academy of Sciences…
- 10 December 1996
The products noted above account quantitatively for virtually all of the GSNO nitrogen consumed during the reaction, and it is now possible to construct a complete set of pathways for the complex transformations arising from GSNO + GSH.