• Publications
  • Influence
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids.
Abstract A new automated system for the analysis of nitrate via reduction with a high-pressure cadmium column is described. Samples of urine, saliva, deproteinized plasma, gastric juice, and milk canExpand
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The chemistry of DNA damage from nitric oxide and peroxynitrite.
Nitric oxide is a key participant in many physiological pathways; however, its reactivity gives it the potential to cause considerable damage to cells and tissues in its vicinity. Nitric oxide canExpand
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Arsenic Exposure Perturbs the Gut Microbiome and Its Metabolic Profile in Mice: An Integrated Metagenomics and Metabolomics Analysis
  • Kun Lu, R. Abo, +6 authors J. Fox
  • Biology, Medicine
  • Environmental health perspectives
  • 10 January 2014
Background: The human intestine is host to an enormously complex, diverse, and vast microbial community—the gut microbiota. The gut microbiome plays a profound role in metabolic processing, energyExpand
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DNA damage and mutation in human cells exposed to nitric oxide in vitro.
Nitric oxide (NO.) is a physiological messenger formed by several cell types. Reaction with O2 forms oxides that nitrosate amines at pH values near 7. We now report experiments in which NO. was addedExpand
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Reactive nitrogen species in the chemical biology of inflammation.
The preponderance of epidemiological evidence now points to a strong association between chronic inflammation and cancers of several organs, including the gastrointestinal tract, liver, and lungs.Expand
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Nitrate biosynthesis in man.
Nitrate metabolism was investigated in long-term metabolic studies in healthy young men. Under conditions of constant low ingestion of nitrate (less than 180 mumol/day per subject), the amount ofExpand
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Gender- and smoking-related bladder cancer risk.
BACKGROUND There is growing evidence that, when smoking habits are comparable, women incur a higher risk of lung cancer than men. Because smokers are also at risk for bladder cancer, we investigatedExpand
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Serum albumin adducts in the molecular epidemiology of aflatoxin carcinogenesis: correlation with aflatoxin B1 intake and urinary excretion of aflatoxin M1.
Aflatoxin-serum albumin adducts in the blood of 42 residents of Guangxi Province, People's Republic of China, were determined and compared with intake of aflatoxin B1 (AFB1) and excretion ofExpand
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A microscale in vitro physiological model of the liver: predictive screens for drug metabolism and enzyme induction.
In vitro models of the liver using isolated primary hepatocytes have been used as screens for measuring the metabolism, toxicity and efficacy of xenobiotics, for studying hepatocyte proliferation,Expand
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A MODEL FOR GASTRIC CANCER EPIDEMIOLOGY
It is postulated that one major subtype of gastric carcinoma ("intestinal type") is the end- result of a series of mutations and cell transformation begun in the first decade of life. The mutagenExpand
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