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Accelerated telomere shortening in response to life stress.
Evidence is provided that psychological stress--both perceived stress and chronicity of stress--is significantly associated with higher oxidative stress, lower telomerase activity, and shorter telomere length, in peripheral blood mononuclear cells from healthy premenopausal women. Expand
Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging
It is shown that mice expressing a proofreading-deficient version of the mitochondrial DNA polymerase g (POLG) accumulate mt DNA mutations and display features of accelerated aging, suggesting that accumulation of mtDNA mutations that promote apoptosis may be a central mechanism driving mammalian aging. Expand
A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.
It is found that a series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase mechanism involving free radical-catalyzed peroxidation of arachidonic acid, and that these prostanoids may participate as pathophysiological mediators in oxidant injury. Expand
Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells.
It is reported that PGE2 treatment of human colon cancer cells leads to increased clonogenicity of HCA-7, but not HCT-116 cells, which may help to explain a component of the mechanism by which COX inhibitors prevent colorectal cancer in humans. Expand
Measurement of F(2)-isoprostanes as an index of oxidative stress in vivo.
Recently, an assay for a urinary metabolite of F(2)-IsoPs is developed, which should provide a valuable noninvasive integrated approach to assess total endogenous production of F (2)isoprostanes in large clinical studies. Expand
Acetylcholine‐induced endothelium‐dependent contractions in the SHR aorta: the Janus face of prostacyclin
In the aorta of SHR and aging WKY, the endothelium‐dependent contractions elicited by acetylcholine most likely involve the release of PGI2 with a concomitant contribution of PGH2. Expand
Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta.
It is demonstrated herein that COX2-derived prostacyclin (PGI2) is the primary PG that is essential for implantation and decidualization, and several lines of evidence suggest that the effects of PGI2 are mediated by its activation of the nuclear hormone receptor PPARdelta, demonstrating the first reported biologic function of this receptor signaling pathway. Expand
A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice
Resveratrol, at doses that can be readily achieved in humans, fulfills the definition of a dietary compound that mimics some aspects of CR, andGene expression profiling suggests that both CR and resver atrol may retard some aspect of aging through alterations in chromatin structure and transcription. Expand
Metabolism of the Endocannabinoids, 2-Arachidonylglycerol and Anandamide, into Prostaglandin, Thromboxane, and Prostacyclin Glycerol Esters and Ethanolamides*
The results define the in vitrodiversity of endocannabinoid-derived prostanoids and will permit focused investigations into their production and potential biological actions in vivo. Expand
Quantification of Isoprostanes as Indices of Oxidant Stress and the Risk of Atherosclerosis in Humans
  • J. Morrow
  • Chemistry, Medicine
  • Arteriosclerosis, thrombosis, and vascular…
  • 9 December 2004
Current evidence suggests that the F2-isoprostanes represent a biomarker that has the potential to be of great importance in the assessment of human atherosclerotic cardiovascular disease. Expand