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Prostaglandins and Inflammation
Prostaglandins are lipid autacoids derived from arachidonic acid. They both sustain homeostatic functions and mediate pathogenic mechanisms, including the inflammatory response. They are generated… Expand
Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities.
Inhibitors selective for prostaglandin G/H synthase-2 (PGHS-2) (known colloquially as COX-2) were designed to minimize gastrointestinal complications of traditional NSAIDs--adverse effects attributed… Expand
A Functional Genomics Strategy Reveals Rora as a Component of the Mammalian Circadian Clock
The mammalian circadian clock plays an integral role in timing rhythmic physiology and behavior, such as locomotor activity, with anticipated daily environmental changes. The master oscillator… Expand
Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2.
- B. McAdam, F. Catella-Lawson, I. Mardini, S. Kapoor, J. Lawson, G. FitzGerald
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 5 January 1999
Prostaglandins (PG) are synthesized by two isoforms of the enzyme PG G/H synthase [cyclooxygenase (COX)]. To examine selectivity of tolerated doses of an inhibitor of the inducible COX-2 in humans,… Expand
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis
Haematopoietic stem cell (HSC) homeostasis is tightly controlled by growth factors, signalling molecules and transcription factors. Definitive HSCs derived during embryogenesis in the… Expand
BMAL1 and CLOCK, Two Essential Components of the Circadian Clock, Are Involved in Glucose Homeostasis
Circadian timing is generated through a unique series of autoregulatory interactions termed the molecular clock. Behavioral rhythms subject to the molecular clock are well characterized. We… Expand
COX-2 and beyond: approaches to prostaglandin inhibition in human disease
- G. FitzGerald
- Nature Reviews Drug Discovery
- 1 November 2003
Selective inhibitors of cyclooxygenase (COX)-2 afford relief from pain and inflammation. They could also prove useful in the chemoprevention of cancer and are being investigated in a range of… Expand
Platelet-active drugs: the relationships among dose, effectiveness, and side effects: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.
This article discusses platelet active drugs as part of the Seventh American College of Chest Physicians Conference on Antithrombotic and Thrombolytic Therapy: Evidence-Based Guidelines. New data on… Expand
Oxidative stress and cardiovascular injury: Part II: animal and human studies.
This review so far has considered the role of vascular cells in the generation of reactive oxygen species (ROS) and novel approaches to their detection in integrated systems such as animal models of… Expand
Cardiovascular outcomes with etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a…
- C. Cannon, S. Curtis, G. FitzGerald, H. Krum, for the Medal Steering Committee
- The Lancet
- 18 November 2006
BACKGROUND Cyclo-oxygenase-2 (COX-2) selective inhibitors have been associated with an increased risk of thrombotic cardiovascular events in placebo-controlled trials, but no clinical trial has been… Expand