• Publications
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Prostaglandins and Inflammation
ins biology has potential clinical relevance for atherosclerosis, the response to vascular injury and aortic aneurysm, and the roles of individual mediators and their receptors in modulating the inflammatory response. Expand
Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities.
Questions that remain to be addressed are whether this hazard extends to all or some of the traditional NSAIDs; whether adjuvant therapies, such as low-dose aspirin, will mitigate the hazard and if so, at what cost; whether COX-2 inhibitors result in cardiovascular risk transformation during chronic dosing; and how to identify individuals most likely to benefit or suffer from such drugs in the future. Expand
A Functional Genomics Strategy Reveals Rora as a Component of the Mammalian Circadian Clock
Results suggest that opposing activities of the orphan nuclear receptors Rora and Rev-erb alpha, which represses Bmal1 expression, are important in the maintenance of circadian clock function. Expand
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis
The conserved role for PGE2 in the regulation of vertebrate HSC homeostasis indicates that modulation of the prostaglandin pathway may facilitate expansion of HSC number for therapeutic purposes. Expand
Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2.
Prostaglandins (PG) are synthesized by two isoforms of the enzyme PG G/H synthase [cyclooxygenase (COX)]. To examine selectivity of tolerated doses of an inhibitor of the inducible COX-2 in humans,Expand
BMAL1 and CLOCK, Two Essential Components of the Circadian Clock, Are Involved in Glucose Homeostasis
Bmal1 and Clock, genes that function in the core molecular clock, exert profound control over recovery from insulin-induced hypoglycaemia and asynchronous dietary cues may modify glucose homeostasis via their interactions with peripheral molecular clocks. Expand
COX-2 and beyond: approaches to prostaglandin inhibition in human disease
  • G. FitzGerald
  • Medicine
  • Nature Reviews Drug Discovery
  • 1 November 2003
The role of COX-2 inhibitors in a number of indications, including cardiovascular disease, hypertension and atherosclerosis are reviewed. Expand
Understanding multicellular function and disease with human tissue-specific networks
NetWAS is introduced, which combines genes with nominally significant genome-wide association study (GWAS) P values and tissue-specific networks to identify disease-gene associations more accurately than GWAS alone. Expand
Genetic and pharmacological analysis of prostanoid receptor function.
The current status of the studies on membrane prostanoid receptor biology is described, and the clinical potential of receptor-selective drugs is discussed and the current evidence for activation of nuclear receptors by prostanoids is critically examined. Expand
Platelet-active drugs: the relationships among dose, effectiveness, and side effects: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.
There is an expanding role for the combination of aspirin and clopidogrel in the long-term management of high-risk patients and the cardiovascular effects of selective and nonselective cyclooxygenase-2 inhibitors have been the subject of increasing attention. Expand