Thiorphan

Known as: (3-Mercapto-2-benzylpropionyl)glycine, Glycine, N-(2-(mercaptomethyl)-1-oxo-3-phenylpropyl)-, (+-)-, Thiorphan [Chemical/Ingredient] 
A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone… (More)
National Institutes of Health

Papers overview

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2016
2016
Impaired angiogenesis is a common pathological characteristic of chronic wounds. Therefore, the regulation of angiogenesis is… (More)
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2014
2014
PURPOSE New compounds with neprilysin or neutral endopeptidase (NEP) inhibiting activity are under clinical investigation in… (More)
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2012
2012
Our interest focused on an open question whether AT-(1-7), nonpeptide receptor agonist: AVE 0991, is able to ameliorate… (More)
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2006
2006
An accumulation of amyloid beta peptide (Abeta) due to an imbalance between anabolism and catabolism triggers Alzheimer's disease… (More)
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2006
2006
Excitotoxic damage appears to be a critical factor in the formation of perinatal brain lesions associated with cerebral palsy (CP… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND The formation of angiotensin-(1-7) from either angiotensin (Ang) I or Ang II in failing human hearts is not well… (More)
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Highly Cited
2001
Highly Cited
2001
To identify the amyloid beta peptide (Abeta) 1-42-degrading enzyme whose activity is inhibited by thiorphan and phosphoramidon in… (More)
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1988
1988
Neurotensin induced significant antinociceptive activity as measured in a variety of nociceptive tests 10 and 30 min following… (More)
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1984
1984
Opiates are known to be reinforcing when injected into the ventral tegmental area (VTA). The present study produced conditioned… (More)
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1983
1983
The effects of various i.v. doses of morphine (0.1, 0.3 and 1 mg/kg) and of thiorphan, an inhibitor of enkephalinase (0.7, 2.5, 5… (More)
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