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Thiorphan

Known as: (3-Mercapto-2-benzylpropionyl)glycine, Glycine, N-(2-(mercaptomethyl)-1-oxo-3-phenylpropyl)-, (+-)-, Thiorphan [Chemical/Ingredient] 
A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone… Expand
National Institutes of Health

Papers overview

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2007
2007
Atrial natriuretic peptide (ANP) stimulates lipolysis in human adipocyte through a cGMP signalling pathway, the regulation of… Expand
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Highly Cited
2003
Highly Cited
2003
Background—The formation of angiotensin-(1-7) from either angiotensin (Ang) I or Ang II in failing human hearts is not well… Expand
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Highly Cited
2001
Highly Cited
2001
To identify the amyloid β peptide (Aβ) 1–42-degrading enzyme whose activity is inhibited by thiorphan and phosphoramidon in vivo… Expand
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Neutral endopeptidase (NEP) degrades vasoactive peptides, including the natriuretic peptides, angiotensin II, and… Expand
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Review
1996
Review
1996
A critical processing step in endothelin biosynthesis is the conversion of the intermediate "big endothelin" to its biologically… Expand
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Highly Cited
1995
Highly Cited
1995
Endothelins (ET) are a family of potent vasoactive peptides that are produced from biologically inactive intermediates, termed… Expand
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Highly Cited
1994
Highly Cited
1994
Endothelin (ET) is a 21-residue potent vasoconstrictive peptide produced by vascular endothelial cells and formed from its… Expand
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Highly Cited
1992
Highly Cited
1992
Neuropeptides such as neurokinin A (NKA) have been proposed as important mediators of bronchoconstriction and airway… Expand
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Highly Cited
1985
Highly Cited
1985
Synthese de la N-[mercaptomethyl-2 phenyl-3 propionyl] glycine(thiorphane) a partir d'oxazolidones-2 substituees 
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Highly Cited
1983
Highly Cited
1983
The effects of various i.v. doses of morphine (0.1, 0.3 and 1 mg/kg) and of thiorphan, an inhibitor of enkephalinase (0.7, 2.5, 5… Expand
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