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Thiorphan

Known as: (3-Mercapto-2-benzylpropionyl)glycine, Glycine, N-(2-(mercaptomethyl)-1-oxo-3-phenylpropyl)-, (+-)-, Thiorphan [Chemical/Ingredient] 
A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone… 
National Institutes of Health

Related topics

Related topics

14 relations
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Broader (1)

Protease Inhibitors

Narrower (6)

S-acetylthiorphanazidothiorphandexecadotrilleucine thiorphan

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
RACECADOTRIL IN THE TREATMENT OF ACUTE DIARRHEA IN CHILDREN: A META-ANALYSIS
Diarrhea has been the subject of considerable attention and effort. A variety of anti-secretory agents have been subjected to… 
2005
2005
Abstracts of papers
s of Papers Presented at the 2nd European Conference on Social Media ECSM 2015 School of Accounting and Administration at the… 
2004
2004
Racecadotril-is there enough evidence to recommend it for treatment of acute diarrhea?
Racecadotril is being proposed as a new “wonder” drug for the treatment of acute diarrhea in children. It is a synthetic… 
2003
2003
Effects of the neutral endopeptidase inhibitor thiorphan on cardiovascular and renal function in cirrhotic rats
Cirrhosis is associated with cardiovascular and renal dysfunction including sodium retention. Many vasoactive peptides such as… 
1994
1994
Effect of an inhaled neutral endopeptidase inhibitor, thiorphan, on airway responsiveness to leukotriene D4 in normal and asthmatic subjects.
Cysteinyl leukotrienes are potent inflammatory mediators that are considered to play a role in the pathophysiology of asthma. It… 
1992
1992
A novel class of enkephalinase inhibitors containing a C-terminal sulfo group.
A new series of sulfonic acids were synthesized and tested for their enkephalinase inhibitory activity. Among them, the most… 
1990
1990
Inhibitors of peptidases: how they influence the biological activities of substance P, neurokinins, bradykinin and angiotensin in guinea pig, hamster and rat urinary bladders.
Neurokinins, bradykinin and angiotensins were tested in isolated urinary bladder of the guinea pig, the hamster and the rat, in… 
1987
1987
The use of a monoclonal antibody for the rapid purification of kidney neutral endopeptidase ("enkephalinase") solubilized in octyl glucoside.
The neutral endopeptidase ("enkephalinase") of the rabbit brush border membrane has been purified to homogeneity by a rapid… 
1986
1986
1H NMR configurational correlation for retro-inverso dipeptides: application to the determination of the absolute configuration of "enkephalinase" inhibitors. Relationships between stereochemistry…
A stereospecific synthesis of thiorphan [N-[2(RS)-(mercaptomethyl)-1-oxo-3-phenylpropyl]glycine] and retro-thiorphan [3-[[1(RS… 
1984
1984
The mu rather than the delta subtype of opioid receptors appears to be involved in enkephalin-induced analgesia.
The analgesic activity of some opioid peptides which display a relative selectivity for either the mu-receptor subtype, [D-Ala2… 
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