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Distinct mechanism for antidepressant activity by blockade of central substance P receptors.
The localization of substance P in brain regions that coordinate stress responses and receive convergent monoaminergic innervation suggested that substance P antagonists might have psychotherapeutic…
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The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways
TLDR
Data show that SNS is involved in pain pathways and suggest that blockade of SNS expression or function may produce analgesia without side effects, and show that TTX-resistant sodium channel α subunit is encoded by the sns gene.
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Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X 3 receptors
TLDR
It is demonstrated that ablation of the P2X3 gene results in the loss of rapidly desensitizing ATP-gated cation currents in dorsal root ganglion neurons, and that the responses of nodose ganglions neurons to ATP show altered kinetics and pharmacology resulting from the lost expression of P2 X2/3 heteromultimers.
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Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn
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Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein
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Sumatriptan Inhibits Neurogenic Vasodilation of Dural Blood Vessels in the Anaesthetized Rat—Intravital Microscope Studies
TLDR
The experimental data indicate that sumatriptan attenuates neurogenic vasodilation, probably by inhibiting the release of CGRP from perivascular trigeminal nerve endings innervating the dura, and parallel the clinical findings that C GRP levels are elevated in migraine and normalized, concomitantly with headache relief, by sum atriptan.
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Intravital Microscope Studies on the Effects of Neurokinin Agonists and Calcitonin Gene-Related Peptide on Dural Vessel Diameter in the Anaesthetized Rat
TLDR
The present experiments indicate that substance P or neurokinin A (both acting through NK1 receptors) or CGRP may be responsible for dural vasodilation within the meningeal vasculature.
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Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach.
Recent studies have shown that there are two isoforms of cyclooxygenases. The constitutive form, cyclooxygenase 1 (COX-1), is believed to be involved in the maintenance of physiological functions. A…
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Cloning, characterization and central nervous system distribution of receptor activity modifying proteins in the rat
TLDR
Cloned the rat RAMP family and characterized the pharmacology of rat CGRP and ADM receptors allow predictions to be made of where each RAMP protein may heterodimerize with its partner G‐protein‐coupled receptor(s) at the cellular level and consequently advance current understanding of cellular sites of action of C GRP, ADM, amylin and CT.
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The novel anti-migraine agent rizatriptan inhibits neurogenic dural vasodilation and extravasation.
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