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Drosophila male sex peptide inhibits siesta sleep and promotes locomotor activity in the post-mated female
The results suggest that SP is the molecular switch that promotes wakefulness in the post-mated female, a change of behaviour compatible with increased foraging and egg-laying activity. Expand
Cloning and Expression of an Evolutionary Conserved Single-domain Angiotensin Converting Enzyme from Drosophila melanogaster(*)
An apparent single-domain (67 kDa) insect angiotensin converting enzyme (AnCE) in embryos of Drosophila melanogaster is identified and the cloning and expression of a Drosophile AnCE cDNA is reported which codes for a single- domain 615-amino acid protein with a predicted 17-AMino acid signal peptide and regions with high levels of homology to both the N- and C-domains of mammalian somatic ACE. Expand
Expression and Functional Characterization of aDrosophila Neuropeptide Precursor with Homology to Mammalian Preprotachykinin A*
Analysis of the Drosophila genome allowed us to identify a putative tachykinin-related peptide prohormone (prepro-DTK) gene, which encodes five novel D rosophila tachyKinin- related peptides (called DTK peptides) with conserved C-terminal FXGXR-amide motifs common to other insect tachy Kinin-based peptides. Expand
Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides
Ang II showed selective competitive inhibition of the carboxy-terminal domain of human somatic ACE providing evidence for a regulatory role in the human renin-angiotensin system (RAS). Expand
Mechanisms of parasite-induced sex reversal in Gammarus duebeni.
Comparing the morphology of the gonad and activity of the androgenic gland, which coordinates male sexual differentiation, in infected and uninfected animals shows that the parasite manipulates host sex by preventing androgensic gland differentiation, androgenics gland hormone production and consequently male differentiation. Expand
Neuronal expression of tachykinin‐related peptides and gene transcript during postembryonic development of Drosophila
The continuous expression of TRPs in neurons throughout postembryonic development suggests specific functional roles in both larval and imaginal flies and possibly also in some neurons during pupal development. Expand
Antibacterial and proteolytic activity in venom from the endoparasitic wasp Pimpla hypochondriaca (Hymenoptera: Ichneumonidae).
Venom from the endoparasitic wasp, Pimpla hypochondriaca, is composed of a mixture of high and low molecular weight proteins, possesses phenoloxidase activity, has immunosuppressive properties, andExpand
Angiotensin I-converting enzyme (ACE) activity of the tomato moth, Lacanobia oleracea: changes in levels of activity during development and after copulation suggest roles during metamorphosis and
The properties of an ACE are reported in a lepidopteran species (the tomato moth, Lacanobia oleracea) and new physiological roles for the enzyme are suggested and it is suggested that the increase in ACE activity might be of general importance for peptide metabolism during metamorphosis in holometabolous insects. Expand
The Drosophila melanogaster-related angiotensin-I-converting enzymes Acer and Ance--distinct enzymic characteristics and alternative expression during pupal development.
The two Drosophila ACEs are alternatively expressed in stages P1 (white puparium)-P15 (eclosion) of pupal development; Ance is expressed predominantly during stages P4-P7, whereas the ACE activity expressed during stages Lisinopril and fosinoprilat were less potent, mainly due to Acer suggesting different roles for the two enzymes during pupalDevelopment. Expand
An Essential Role in Molting and Morphogenesis of Caenorhabditis elegans for ACN-1, a Novel Member of the Angiotensin-converting Enzyme Family That Lacks a Metallopeptidase Active Site*
It is proposed that alteration of the ancestral ACE during evolution, by loss of the metallopeptidase active site and the addition of new protein modules, has provided opportunities for novel molecular interactions important for post-embryonic development in nematodes. Expand