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Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ischemic brain injury.
TLDR
The enhanced activity of EUK-134 suggests that, in particular, hydrogen peroxide contributes significantly to this injury, and suggests that synthetic SOD/catalase mimetics might serve as novel, multifunctional therapeutic agents for stroke.
Extension of life-span with superoxide dismutase/catalase mimetics.
TLDR
It appears that oxidative stress is a major determinant of life-span and that it can be counteracted by pharmacological intervention.
Salen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: structure-activity relationship studies.
TLDR
Structural modification of the prototype EUK-8 yields compounds with enhanced catalase activity and, in turn, biological effectiveness, which supports the concept that salen-manganese complexes represent a class of SOD andCatalase mimetics potentially useful against ROS-associated diseases.
The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice
TLDR
Thiorphan is reported here that this compound, thiorphan [(DL-3-mercapto-2-benzylpropanoyl)-glycine; patent no. 8008601] protects the enkephalins from the action of enkephalinase in vitro in nanomolar concentration and in vivo after either intracerebroventricular or systemic administration.
Anti-transferrin receptor antibody and antibody-drug conjugates cross the blood-brain barrier.
TLDR
Capillary-depletion experiments, in which the brain is separated into capillary and parenchymal fractions, show a time-dependent migration of radiolabeled antibody from the capillaries into the brain parenchyma, which is consistent with the transcytosis of compounds across the blood-brain barrier.
Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics
TLDR
A dramatic loss of learning and memory function from 8 to 11 months of age in mice, associated with marked increases in several markers of brain oxidative stress, is reported and the role of reactive oxygen species in age-related learning impairment is supported.
Lifespan Extension and Rescue of Spongiform Encephalopathy in Superoxide Dismutase 2 Nullizygous Mice Treated with Superoxide Dismutase–Catalase Mimetics
TLDR
It is shown that treatment of sod2 nullizygous mice with synthetic superoxide dismutase (SOD)–catalase mimetics extends their lifespan by threefold, rescues the spongiform encephalopathy, and attenuates mitochondrial defects.
EUK-8, a synthetic superoxide dismutase and catalase mimetic, ameliorates acute lung injury in endotoxemic swine.
TLDR
It is concluded that EUK-8 prevents many of the manifestations of LPS-induced adult respiratory distress syndrome in pigs by detoxifying reactive oxygen metabolites without affecting the release of other important proinflammatory mediators.
Biological inactivation of enkephalins and the role of enkephalin-dipeptidyl-carboxypeptidase ("enkephalinase") as neuropeptidase.
TLDR
Three types of well defined peptidase activities in CNS may account for the hydrolysis of the opioid pentapeptides : aminopeptidases, angiotensin-converting enzyme and enkephalin-dipeptidylcarboxypeptidase.
beta-Amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8, a synthetic catalytic free radical scavenger.
TLDR
A role for oxygen free radicals in beta-AP toxicity is supported and the therapeutic potential of synthetic radical scavengers in Alzheimer disease is highlighted.
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